Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide

DE REQUENA D GONZÁLEZ; Andrea CALCAGNO; Stefano BONORA; L LADETTO; ANTONIO D'AVOLIO; M SCIANDRA; M SICCARDI; O BARGIACCHI; Alessandro SINICCO; Giovanni DI PERRI

Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide

DE REQUENA D GONZÁLEZ
, Andrea CALCAGNO
, Stefano BONORA
, L LADETTO
, ANTONIO D'AVOLIO
, M SCIANDRA
, M SICCARDI
, O BARGIACCHI
, Alessandro SINICCO
, Giovanni DI PERRI

Department of Translational Medicine

Research output: Contribution to journal › Article

Abstract

Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.

Original language	English
Pages (from-to)	1977-1979
Number of pages	3
Journal	AIDS
Volume	20
Publication status	Published - 2006

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title = "Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide",

abstract = "Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.",

author = "GONZ{\'A}LEZ, \{DE REQUENA D\} and Andrea CALCAGNO and Stefano BONORA and L LADETTO and ANTONIO D'AVOLIO and M SCIANDRA and M SICCARDI and O BARGIACCHI and Alessandro SINICCO and \{DI PERRI\}, Giovanni",

year = "2006",

language = "English",

volume = "20",

pages = "1977--1979",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide

AU - GONZÁLEZ, DE REQUENA D

AU - CALCAGNO, Andrea

AU - BONORA, Stefano

AU - LADETTO, L

AU - D'AVOLIO, ANTONIO

AU - SCIANDRA, M

AU - SICCARDI, M

AU - BARGIACCHI, O

AU - SINICCO, Alessandro

AU - DI PERRI, Giovanni

PY - 2006

Y1 - 2006

N2 - Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.

AB - Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug-drug interaction warrants further investigation.

UR - https://iris.uniupo.it/handle/11579/216976

M3 - Article

SN - 0269-9370

VL - 20

SP - 1977

EP - 1979

JO - AIDS

JF - AIDS

ER -

Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide

Abstract

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