Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Alberto Mantovani; Paola Allavena; Antonio Sica

doi:10.1016/j.ejca.2004.03.016

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Alberto Mantovani, Paola Allavena, Antonio Sica

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

Original language	English
Pages (from-to)	1660-1667
Number of pages	8
Journal	European Journal of Cancer
Volume	40
Issue number	11
DOIs	https://doi.org/10.1016/j.ejca.2004.03.016
Publication status	Published - Jul 2004
Externally published	Yes

Keywords

Polarised phagocyte populations
Tumour progression
Tumour-associated macrophages

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2004.03.016

Cite this

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title = "Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression",

abstract = "Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.",

keywords = "Polarised phagocyte populations, Tumour progression, Tumour-associated macrophages",

author = "Alberto Mantovani and Paola Allavena and Antonio Sica",

year = "2004",

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language = "English",

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T1 - Tumour-associated macrophages as a prototypic type II polarised phagocyte population

T2 - Role in tumour progression

AU - Mantovani, Alberto

AU - Allavena, Paola

AU - Sica, Antonio

PY - 2004/7

Y1 - 2004/7

N2 - Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

AB - Macrophages are versatile, plastic cells which respond to micro-environmental signals with distinct functional programmes. In the tumour microenvironment, tumour-associated macrophages (TAM) polarise towards a type II phenotype, oriented to the promotion of tissue remodelling and repair. As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression.

KW - Polarised phagocyte populations

KW - Tumour progression

KW - Tumour-associated macrophages

UR - http://www.scopus.com/inward/record.url?scp=3142644996&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2004.03.016

DO - 10.1016/j.ejca.2004.03.016

M3 - Article

SN - 0959-8049

VL - 40

SP - 1660

EP - 1667

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 11

ER -

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression

Abstract

Keywords

UN SDGs

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