Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

Alberto Mantovani; Antonio Sica; Paola Allavena; Cecilia Garlanda; Massimo Locati

doi:10.1016/j.humimm.2009.02.008

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

Alberto Mantovani, Antonio Sica, Paola Allavena, Cecilia Garlanda, Massimo Locati

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.

Original language	English
Pages (from-to)	325-330
Number of pages	6
Journal	Human Immunology
Volume	70
Issue number	5
DOIs	https://doi.org/10.1016/j.humimm.2009.02.008
Publication status	Published - May 2009

Keywords

Cancer
Cancer-related inflammation
Cytokines
Inflammation
Macrophages
Monocytes
Myeloid-derived suppressor cells
Polarization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.humimm.2009.02.008

Cite this

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title = "Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation",

abstract = "Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.",

keywords = "Cancer, Cancer-related inflammation, Cytokines, Inflammation, Macrophages, Monocytes, Myeloid-derived suppressor cells, Polarization",

author = "Alberto Mantovani and Antonio Sica and Paola Allavena and Cecilia Garlanda and Massimo Locati",

note = "Funding Information: This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC) and CARIPLO Nobel project.",

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T1 - Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

AU - Mantovani, Alberto

AU - Sica, Antonio

AU - Allavena, Paola

AU - Garlanda, Cecilia

AU - Locati, Massimo

N1 - Funding Information: This work was supported by Associazione Italiana per la Ricerca sul Cancro (AIRC) and CARIPLO Nobel project.

PY - 2009/5

Y1 - 2009/5

N2 - Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.

AB - Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.

KW - Cancer

KW - Cancer-related inflammation

KW - Cytokines

KW - Inflammation

KW - Macrophages

KW - Monocytes

KW - Myeloid-derived suppressor cells

KW - Polarization

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U2 - 10.1016/j.humimm.2009.02.008

DO - 10.1016/j.humimm.2009.02.008

M3 - Article

SN - 0198-8859

VL - 70

SP - 325

EP - 330

JO - Human Immunology

JF - Human Immunology

IS - 5

ER -

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

Abstract

Keywords

UN SDGs

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