Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents

Irene Preet Bhela, Marta Serafini, Erika Del Grosso, Gian Cesare Tron, Tracey Pirali

Research output: Contribution to journalArticlepeer-review

Abstract

Starting from a wide range of α-acylamino amide substructures synthesized using tritylamine as an ammonia surrogate in the Ugi reaction, Burgess-type reagents enable cyclodehydration and afford unprecedented oxazole scaffolds with four points of diversity, including a sulfamide moiety in the 5-position. The synthetic procedure employs readily available starting materials and proceeds smoothly under mild reaction conditions with good tolerance for a variety of functional groups, coming to fill a gap in the field of oxazole compounds.

Original languageEnglish
Pages (from-to)3610-3614
Number of pages5
JournalOrganic Letters
Volume23
Issue number9
DOIs
Publication statusPublished - 7 May 2021

Fingerprint

Dive into the research topics of 'Tritylamine as an ammonia surrogate in the ugi reaction provides access to unprecedented 5-sulfamido oxazoles using burgess-type reagents'. Together they form a unique fingerprint.

Cite this