Abstract
Starting from a wide range of α-acylamino amide substructures synthesized using tritylamine as an ammonia surrogate in the Ugi reaction, Burgess-type reagents enable cyclodehydration and afford unprecedented oxazole scaffolds with four points of diversity, including a sulfamide moiety in the 5-position. The synthetic procedure employs readily available starting materials and proceeds smoothly under mild reaction conditions with good tolerance for a variety of functional groups, coming to fill a gap in the field of oxazole compounds.
Original language | English |
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Pages (from-to) | 3610-3614 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 23 |
Issue number | 9 |
DOIs | |
Publication status | Published - 7 May 2021 |