Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

D. PUERTA; Mauro BOTTA; C. J. JOCHER; E. J. WERNER; STEFANO AVEDANO; K. N. RAYMOND; S. M. COHEN

doi:10.1021/ja057954f

Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

D. PUERTA
, Mauro BOTTA
, C. J. JOCHER
, E. J. WERNER
, STEFANO AVEDANO
, K. N. RAYMOND
, S. M. COHEN

Department of Science and Technological Innovation

Research output: Contribution to journal › Article

Abstract

Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]^2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.

Original language	English
Pages (from-to)	2222-2223
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
DOIs	https://doi.org/10.1021/ja057954f
Publication status	Published - 2006

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10.1021/ja057954f

http://hdl.handle.net/11579/20587

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title = "Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA",

abstract = "Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.",

author = "D. PUERTA and Mauro BOTTA and JOCHER, \{C. J.\} and WERNER, \{E. J.\} and STEFANO AVEDANO and RAYMOND, \{K. N.\} and COHEN, \{S. M.\}",

year = "2006",

doi = "10.1021/ja057954f",

language = "English",

volume = "128",

pages = "2222--2223",

journal = "Journal of the American Chemical Society",

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publisher = "American Chemical Society",

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T1 - Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

AU - PUERTA, D.

AU - BOTTA, Mauro

AU - JOCHER, C. J.

AU - WERNER, E. J.

AU - AVEDANO, STEFANO

AU - RAYMOND, K. N.

AU - COHEN, S. M.

PY - 2006

Y1 - 2006

N2 - Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.

AB - Two tripodal, hexadentate pyrone-based chelators have been prepared. These ligands form stable, soluble complexes with gadolinium(III). The complexes show aqueous stability comparable to that of [Gd(DTPA)]2- at pH 7.4. Evaluation by relaxometry shows that these complexes have two inner-sphere water molecules and a very fast water exchange rate. The solution behavior of these complexes suggests that they may be attractive as high relaxivity, next-generation magnetic resonance imaging contrast agents.

UR - https://iris.uniupo.it/handle/11579/20587

U2 - 10.1021/ja057954f

DO - 10.1021/ja057954f

M3 - Article

SN - 0002-7863

VL - 128

SP - 2222

EP - 2223

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

ER -

Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA

Abstract

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