Trends in NMR studies of paramagnetic Gd(III) complexes as potential contrast agents in MRI

S. Aime; L. Barbero; M. Botta

doi:10.1016/0730-725X(91)90386-Z

Trends in NMR studies of paramagnetic Gd(III) complexes as potential contrast agents in MRI

S. Aime
, L. Barbero
, M. Botta

Research output: Contribution to journal › Article › peer-review

Abstract

The paramagnetic Gd(III) complexes with polyaminocarboxylate ligands are intensively studied as possible Contrast Agents for Magnetic Resonance Imaging (M.R.I.). Their ability to enhance the solvent proton relaxation rate is mainly determined by the molecular reorientational time (τ_R). In order to increase τ_R we studied the formation of non-covalent interactions between functionalized Gd(III)-complexes and micelles. The N.M.R.D. (Nuclear Magnetic Relaxation Dispersion) profiles of aqueous solutions of these paramagnetic complexes with hexadecyltrimethylammonium bromide (CTABr) were measured and the results could be accounted for by difference in negative charge and number of hydrophobic aromatic residues among the different complexes.

Original language	English
Pages (from-to)	843-847
Number of pages	5
Journal	Magnetic Resonance Imaging
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(91)90386-Z
Publication status	Published - 1991
Externally published	Yes

Keywords

Micelles
Non-covalent interaction
Paramagnetic Gd(III) complexes

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10.1016/0730-725X(91)90386-Z

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title = "Trends in NMR studies of paramagnetic Gd(III) complexes as potential contrast agents in MRI",

abstract = "The paramagnetic Gd(III) complexes with polyaminocarboxylate ligands are intensively studied as possible Contrast Agents for Magnetic Resonance Imaging (M.R.I.). Their ability to enhance the solvent proton relaxation rate is mainly determined by the molecular reorientational time (τR). In order to increase τR we studied the formation of non-covalent interactions between functionalized Gd(III)-complexes and micelles. The N.M.R.D. (Nuclear Magnetic Relaxation Dispersion) profiles of aqueous solutions of these paramagnetic complexes with hexadecyltrimethylammonium bromide (CTABr) were measured and the results could be accounted for by difference in negative charge and number of hydrophobic aromatic residues among the different complexes.",

keywords = "Micelles, Non-covalent interaction, Paramagnetic Gd(III) complexes",

author = "S. Aime and L. Barbero and M. Botta",

year = "1991",

doi = "10.1016/0730-725X(91)90386-Z",

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pages = "843--847",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Trends in NMR studies of paramagnetic Gd(III) complexes as potential contrast agents in MRI

AU - Aime, S.

AU - Barbero, L.

AU - Botta, M.

PY - 1991

Y1 - 1991

N2 - The paramagnetic Gd(III) complexes with polyaminocarboxylate ligands are intensively studied as possible Contrast Agents for Magnetic Resonance Imaging (M.R.I.). Their ability to enhance the solvent proton relaxation rate is mainly determined by the molecular reorientational time (τR). In order to increase τR we studied the formation of non-covalent interactions between functionalized Gd(III)-complexes and micelles. The N.M.R.D. (Nuclear Magnetic Relaxation Dispersion) profiles of aqueous solutions of these paramagnetic complexes with hexadecyltrimethylammonium bromide (CTABr) were measured and the results could be accounted for by difference in negative charge and number of hydrophobic aromatic residues among the different complexes.

AB - The paramagnetic Gd(III) complexes with polyaminocarboxylate ligands are intensively studied as possible Contrast Agents for Magnetic Resonance Imaging (M.R.I.). Their ability to enhance the solvent proton relaxation rate is mainly determined by the molecular reorientational time (τR). In order to increase τR we studied the formation of non-covalent interactions between functionalized Gd(III)-complexes and micelles. The N.M.R.D. (Nuclear Magnetic Relaxation Dispersion) profiles of aqueous solutions of these paramagnetic complexes with hexadecyltrimethylammonium bromide (CTABr) were measured and the results could be accounted for by difference in negative charge and number of hydrophobic aromatic residues among the different complexes.

KW - Micelles

KW - Non-covalent interaction

KW - Paramagnetic Gd(III) complexes

UR - https://www.scopus.com/pages/publications/0026315628

U2 - 10.1016/0730-725X(91)90386-Z

DO - 10.1016/0730-725X(91)90386-Z

M3 - Article

SN - 0730-725X

VL - 9

SP - 843

EP - 847

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 5

ER -

Trends in NMR studies of paramagnetic Gd(III) complexes as potential contrast agents in MRI

Abstract

Keywords

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