Transition metal carbonyl clusters in biology: A futile or niche research area?

Aldo Arrais; Elisabetta Gabano; Mauro Ravera; Domenico Osella

doi:10.1016/j.ica.2017.05.021

Transition metal carbonyl clusters in biology: A futile or niche research area?

Aldo Arrais
, Elisabetta Gabano
, Mauro Ravera
, Domenico Osella

Research output: Contribution to journal › Review article › peer-review

Abstract

Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.

Original language	English
Pages (from-to)	3-10
Number of pages	8
Journal	Inorganica Chimica Acta
Volume	470
DOIs	https://doi.org/10.1016/j.ica.2017.05.021
Publication status	Published - 30 Jan 2018

Keywords

Antiproliferative agents
Carbon monoxide releasing molecules
Carbonyl metallo-immunoassay
Protein structural characterization
Transition metal carbonyl clusters

Access to Document

10.1016/j.ica.2017.05.021

Cite this

@article{4a42ff58a5634bfaabb2f152bb572ca5,

title = "Transition metal carbonyl clusters in biology: A futile or niche research area?",

abstract = "Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.",

keywords = "Antiproliferative agents, Carbon monoxide releasing molecules, Carbonyl metallo-immunoassay, Protein structural characterization, Transition metal carbonyl clusters",

author = "Aldo Arrais and Elisabetta Gabano and Mauro Ravera and Domenico Osella",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = jan,

day = "30",

doi = "10.1016/j.ica.2017.05.021",

language = "English",

volume = "470",

pages = "3--10",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Transition metal carbonyl clusters in biology

T2 - A futile or niche research area?

AU - Arrais, Aldo

AU - Gabano, Elisabetta

AU - Ravera, Mauro

AU - Osella, Domenico

PY - 2018/1/30

Y1 - 2018/1/30

N2 - Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.

AB - Transition metal carbonyl clusters (TMCCs) have seldom been considered in a biological perspective. Albeit generally flawed with low water-solubility and poor air-stability, drawbacks typical of all the organometallic complexes, selected TMCCs, designed by consolidated synthetic chemical routes, have so far encountered applications in few carefully selected biological fields, thus representing a very niche research area. This paper presents a brief overview of the applications of TMCCs in protein structural characterization, in hormone labelling, in carbonyl metallo-immunoassay (CMIA), as carbon monoxide releasing molecules (CORM) and, finally, as antiproliferative (antitumor) agents.

KW - Antiproliferative agents

KW - Carbon monoxide releasing molecules

KW - Carbonyl metallo-immunoassay

KW - Protein structural characterization

KW - Transition metal carbonyl clusters

UR - https://www.scopus.com/pages/publications/85019383526

U2 - 10.1016/j.ica.2017.05.021

DO - 10.1016/j.ica.2017.05.021

M3 - Review article

SN - 0020-1693

VL - 470

SP - 3

EP - 10

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Transition metal carbonyl clusters in biology: A futile or niche research area?

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this