Tissue Engineering Techniques for the Treatment of a Complex Knee Injury

Mario Ronga; Federico Alberto Grassi; Alessandro Manelli; Paolo Bulgheroni

doi:10.1016/j.arthro.2005.12.050

Tissue Engineering Techniques for the Treatment of a Complex Knee Injury

Mario Ronga, Federico Alberto Grassi, Alessandro Manelli, Paolo Bulgheroni

Research output: Contribution to journal › Article › peer-review

Abstract

We report and discuss the use of and rationale for tissue engineering techniques in a 40-year-old sportsman who suffered simultaneous anterior cruciate ligament (ACL) rupture, irreparable medial meniscal tear, and chondral lesion of the medial femoral condyle. A 2-step treatment was adopted to address all lesions. The first procedures consisted of ACL reconstruction and collagen meniscus implant (CMI), followed 6 months later by autologous chondrocyte implantation on a collagen membrane (MACI). A CMI biopsy was performed 6 months after implantation. Histologic and ultrastructural analysis documented scaffold invasion by cells and newly synthesized connective tissue. At 2-year follow up, the clinical and functional results were good and magnetic resonance imaging showed integration of the meniscal and cartilage implants. In this patient, each lesion needed to be addressed to achieve an optimal outcome. The primary goal was to restore normal joint biomechanics by performing CMI and ACL reconstruction. MACI was an adequate solution for the management of the large (5 cm²) chondral defect.

Original language	English
Pages (from-to)	576.e1-576.e3
Journal	Arthroscopy - Journal of Arthroscopic and Related Surgery
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.arthro.2005.12.050
Publication status	Published - May 2006
Externally published	Yes

Keywords

ACL reconstruction
Biologic meniscal replacement
Cartilage transplant
Collagen scaffold

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10.1016/j.arthro.2005.12.050

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title = "Tissue Engineering Techniques for the Treatment of a Complex Knee Injury",

abstract = "We report and discuss the use of and rationale for tissue engineering techniques in a 40-year-old sportsman who suffered simultaneous anterior cruciate ligament (ACL) rupture, irreparable medial meniscal tear, and chondral lesion of the medial femoral condyle. A 2-step treatment was adopted to address all lesions. The first procedures consisted of ACL reconstruction and collagen meniscus implant (CMI), followed 6 months later by autologous chondrocyte implantation on a collagen membrane (MACI). A CMI biopsy was performed 6 months after implantation. Histologic and ultrastructural analysis documented scaffold invasion by cells and newly synthesized connective tissue. At 2-year follow up, the clinical and functional results were good and magnetic resonance imaging showed integration of the meniscal and cartilage implants. In this patient, each lesion needed to be addressed to achieve an optimal outcome. The primary goal was to restore normal joint biomechanics by performing CMI and ACL reconstruction. MACI was an adequate solution for the management of the large (5 cm2) chondral defect.",

keywords = "ACL reconstruction, Biologic meniscal replacement, Cartilage transplant, Collagen scaffold",

author = "Mario Ronga and Grassi, {Federico Alberto} and Alessandro Manelli and Paolo Bulgheroni",

note = "Funding Information: Supported by the Academic Fund for Research, University of Insubria, Varese, Italy. ",

year = "2006",

month = may,

doi = "10.1016/j.arthro.2005.12.050",

language = "English",

volume = "22",

pages = "576.e1--576.e3",

journal = "Arthroscopy - Journal of Arthroscopic and Related Surgery",

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T1 - Tissue Engineering Techniques for the Treatment of a Complex Knee Injury

AU - Ronga, Mario

AU - Grassi, Federico Alberto

AU - Manelli, Alessandro

AU - Bulgheroni, Paolo

N1 - Funding Information: Supported by the Academic Fund for Research, University of Insubria, Varese, Italy.

PY - 2006/5

Y1 - 2006/5

N2 - We report and discuss the use of and rationale for tissue engineering techniques in a 40-year-old sportsman who suffered simultaneous anterior cruciate ligament (ACL) rupture, irreparable medial meniscal tear, and chondral lesion of the medial femoral condyle. A 2-step treatment was adopted to address all lesions. The first procedures consisted of ACL reconstruction and collagen meniscus implant (CMI), followed 6 months later by autologous chondrocyte implantation on a collagen membrane (MACI). A CMI biopsy was performed 6 months after implantation. Histologic and ultrastructural analysis documented scaffold invasion by cells and newly synthesized connective tissue. At 2-year follow up, the clinical and functional results were good and magnetic resonance imaging showed integration of the meniscal and cartilage implants. In this patient, each lesion needed to be addressed to achieve an optimal outcome. The primary goal was to restore normal joint biomechanics by performing CMI and ACL reconstruction. MACI was an adequate solution for the management of the large (5 cm2) chondral defect.

AB - We report and discuss the use of and rationale for tissue engineering techniques in a 40-year-old sportsman who suffered simultaneous anterior cruciate ligament (ACL) rupture, irreparable medial meniscal tear, and chondral lesion of the medial femoral condyle. A 2-step treatment was adopted to address all lesions. The first procedures consisted of ACL reconstruction and collagen meniscus implant (CMI), followed 6 months later by autologous chondrocyte implantation on a collagen membrane (MACI). A CMI biopsy was performed 6 months after implantation. Histologic and ultrastructural analysis documented scaffold invasion by cells and newly synthesized connective tissue. At 2-year follow up, the clinical and functional results were good and magnetic resonance imaging showed integration of the meniscal and cartilage implants. In this patient, each lesion needed to be addressed to achieve an optimal outcome. The primary goal was to restore normal joint biomechanics by performing CMI and ACL reconstruction. MACI was an adequate solution for the management of the large (5 cm2) chondral defect.

KW - ACL reconstruction

KW - Biologic meniscal replacement

KW - Cartilage transplant

KW - Collagen scaffold

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DO - 10.1016/j.arthro.2005.12.050

M3 - Article

SN - 0749-8063

VL - 22

SP - 576.e1-576.e3

JO - Arthroscopy - Journal of Arthroscopic and Related Surgery

JF - Arthroscopy - Journal of Arthroscopic and Related Surgery

IS - 5

ER -

Tissue Engineering Techniques for the Treatment of a Complex Knee Injury

Abstract

Keywords

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