Thrombin increases the adhesion of washed human platelets to collagen

F. Sinigaglia; C. L. Balduini; A. Bisio; C. Balduini

doi:10.1111/j.1365-2141.1985.tb07352.x

Thrombin increases the adhesion of washed human platelets to collagen

F. Sinigaglia
, C. L. Balduini
, A. Bisio
, C. Balduini

Research output: Contribution to journal › Article › peer-review

Abstract

Summary Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.

Original language	English
Pages (from-to)	587-592
Number of pages	6
Journal	British Journal of Haematology
Volume	59
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1985.tb07352.x
Publication status	Published - Apr 1985
Externally published	Yes

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title = "Thrombin increases the adhesion of washed human platelets to collagen",

abstract = "Summary Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.",

author = "F. Sinigaglia and Balduini, \{C. L.\} and A. Bisio and C. Balduini",

year = "1985",

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AU - Sinigaglia, F.

AU - Balduini, C. L.

AU - Bisio, A.

AU - Balduini, C.

PY - 1985/4

Y1 - 1985/4

N2 - Summary Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.

AB - Summary Thrombin stimulates the adhesion of washed human platelets to fibrillar collagen. This phenomenon occurs also when platelets, before thrombin stimulation, are resuspended in the presence of prostaglandin E1 to minimize the release reaction. Enzymatic activity of thrombin is not necessary for the enhancement of platelet adhesiveness, since phenylmethylsulphonylfluoride inhibited thrombin is effective in this respect. Detachment of thrombin from thrombin treated platelets by the use of hirudin restores normal platelet adhesiveness to collagen.

UR - https://www.scopus.com/pages/publications/0021918810

U2 - 10.1111/j.1365-2141.1985.tb07352.x

DO - 10.1111/j.1365-2141.1985.tb07352.x

M3 - Article

SN - 0007-1048

VL - 59

SP - 587

EP - 592

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Thrombin increases the adhesion of washed human platelets to collagen

Abstract

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