Abstract
Dozens of strategies have been described for the synthesis of α-hydroxyamides over the years, but they share common drawbacks in terms of generality and tolerability, especially to acid labile functionalities. Here we report a truncated Passerini reaction suitable for the easy and mild preparation of functionalized α-hydroxyamides. In particular, this procedure is tolerant to acid sensitive protecting groups, which remain intact during the multicomponent reaction.
Original language | English |
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Pages (from-to) | 4786-4789 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 58 |
Issue number | 51 |
DOIs | |
Publication status | Published - 20 Dec 2017 |
Keywords
- 2-Hydroxymethyl benzoic acid
- Isocyanides
- Multicomponent reactions
- Truncated Passerini reaction
- α-Hydroxyamides