The new antiepileptic drugs: A rational approach

R. Mutani; D. Bettucci; R. Cantello; M. Gianelli; U. Dimanico

The new antiepileptic drugs: A rational approach

R. Mutani
, D. Bettucci
, R. Cantello
, M. Gianelli
, U. Dimanico

Research output: Contribution to journal › Article › peer-review

Abstract

The rational approach to the development of new antiepileptic drugs should be based on knowledge of basic events responsable for epilepsy. Epileptogenesis is caused by impairment of GABA-mediated inhibition, enhancement of excitatory aminoacid neurotransmission and peculiar membrane properties of some pyramidal neurons. A review is made of the new drugs developed as a pharmacological manipulation of the main mechanisms of epileptogenesis.

Original language	English
Pages (from-to)	29-31
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	64
Publication status	Published - 1988
Externally published	Yes

Cite this

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title = "The new antiepileptic drugs: A rational approach",

abstract = "The rational approach to the development of new antiepileptic drugs should be based on knowledge of basic events responsable for epilepsy. Epileptogenesis is caused by impairment of GABA-mediated inhibition, enhancement of excitatory aminoacid neurotransmission and peculiar membrane properties of some pyramidal neurons. A review is made of the new drugs developed as a pharmacological manipulation of the main mechanisms of epileptogenesis.",

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AU - Mutani, R.

AU - Bettucci, D.

AU - Cantello, R.

AU - Gianelli, M.

AU - Dimanico, U.

PY - 1988

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UR - https://www.scopus.com/pages/publications/0024216868

M3 - Article

AN - SCOPUS:0024216868

SN - 0394-560X

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JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

IS - 64

ER -

The new antiepileptic drugs: A rational approach

Abstract

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