The metabolic fate of the anti-Parkinsonian drug budipine in rats

O. Caputo; G. Grosa; M. Ceruti; F. Rocco; G. Biglino

doi:10.1007/BF03189947

The metabolic fate of the anti-Parkinsonian drug budipine in rats

O. Caputo
, G. Grosa
, M. Ceruti
, F. Rocco
, G. Biglino

Research output: Contribution to journal › Article › peer-review

Abstract

The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M₁ N-oxide and a secondary metabolite derived from M₁ via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M₁-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/BF03189947
Publication status	Published - Apr 1991
Externally published	Yes

Keywords

1-tert-butyl-4,4-diphenylpiperidine
BY-701
Budipine
anti-Parkinsonian
metabolism

Access to Document

10.1007/BF03189947

Cite this

@article{42429d31263d400f9535b24c4edbe9a1,

title = "The metabolic fate of the anti-Parkinsonian drug budipine in rats",

abstract = "The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.",

keywords = "1-tert-butyl-4,4-diphenylpiperidine, BY-701, Budipine, anti-Parkinsonian, metabolism",

author = "O. Caputo and G. Grosa and M. Ceruti and F. Rocco and G. Biglino",

year = "1991",

month = apr,

doi = "10.1007/BF03189947",

language = "English",

volume = "16",

pages = "113--118",

journal = "European Journal of Drug Metabolism and Pharmacokinetics",

issn = "0378-7966",

publisher = "Adis",

number = "2",

}

TY - JOUR

T1 - The metabolic fate of the anti-Parkinsonian drug budipine in rats

AU - Caputo, O.

AU - Grosa, G.

AU - Ceruti, M.

AU - Rocco, F.

AU - Biglino, G.

PY - 1991/4

Y1 - 1991/4

N2 - The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

AB - The metabolic fate of the anti-Parkinsonian drug budipine was studied in rats after oral administration. The presence of an aromatic hydroxylation product, metabolite Mi, and its O-sulphate conjugate was confirmed. Three new minor metabolites, budipine N-oxide, metabolite M1 N-oxide and a secondary metabolite derived from M1 via hydroxylation of a methyl of the tert-butyl group, were isolated and identified in rat urine. The presence of a metabolite M1-glucuronic acid conjugate, was also established through different enzymatic treatments of the rat urine.

KW - 1-tert-butyl-4,4-diphenylpiperidine

KW - BY-701

KW - Budipine

KW - anti-Parkinsonian

KW - metabolism

UR - https://www.scopus.com/pages/publications/0025916840

U2 - 10.1007/BF03189947

DO - 10.1007/BF03189947

M3 - Article

SN - 0378-7966

VL - 16

SP - 113

EP - 118

JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 2

ER -

The metabolic fate of the anti-Parkinsonian drug budipine in rats

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this