The left atrial appendage: From embryology to prevention of thromboembolism

Giuseppe Patti; Vittorio Pengo; Rossella Marcucci; Plinio Cirillo; Giulia Renda; Francesca Santilli; Paolo Calabrò; Alberto Ranieri De Caterina; Ilaria Cavallari; Elisabetta Ricottini; Vito Maurizio Parato; Giacomo Zoppellaro; Giuseppe Di Gioia; Pietro Sedati; Vincenzo Cicchitti; Giovanni Davì; Enrica Golia; Ivana Pariggiano; Paola Simeone; Rosanna Abbate; Domenico Prisco; Marco Zimarino; Francesco Sofi; Felicita Andreotti

doi:10.1093/eurheartj/ehw159

The left atrial appendage: From embryology to prevention of thromboembolism

Giuseppe Patti
, Vittorio Pengo
, Rossella Marcucci
, Plinio Cirillo
, Giulia Renda
, Francesca Santilli
, Paolo Calabrò
, Alberto Ranieri De Caterina
, Ilaria Cavallari
, Elisabetta Ricottini
, Vito Maurizio Parato
, Giacomo Zoppellaro
, Giuseppe Di Gioia
, Pietro Sedati
, Vincenzo Cicchitti
, Giovanni Davì
, Enrica Golia
, Ivana Pariggiano
, Paola Simeone
, Rosanna Abbate

Domenico Prisco, Marco Zimarino, Francesco Sofi, Felicita Andreotti

Research output: Contribution to journal › Review article › peer-review

Abstract

The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure and thrombosis. Here we provide baseline notions on the anatomy and function of the LAA, and then focus on current imaging tools for the identification of anatomical varieties. We also describe pathogenetic mechanisms of LAA thrombosis in AF patients, and examine the available evidence on treatment strategies for LAA thrombosis, including the use of non-vitamin K antagonist oral anticoagulants and interventional approaches.

Original language	English
Pages (from-to)	877-887
Number of pages	11
Journal	European Heart Journal
Volume	38
Issue number	12
DOIs	https://doi.org/10.1093/eurheartj/ehw159
Publication status	Published - 21 Mar 2017
Externally published	Yes

Keywords

Anticoagulants
Atrial fibrillation
Left atrial appendage
NOACs
Non-Vitamin K antagonist oral anticoagulants
Occlusion devices
Stroke
Systemic embolism
Thromboembolism

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10.1093/eurheartj/ehw159

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Patti, G., Pengo, V., Marcucci, R., Cirillo, P., Renda, G., Santilli, F., Calabrò, P., De Caterina, A. R., Cavallari, I., Ricottini, E., Parato, V. M., Zoppellaro, G., Di Gioia, G., Sedati, P., Cicchitti, V., Davì, G., Golia, E., Pariggiano, I., Simeone, P., ... Andreotti, F. (2017). The left atrial appendage: From embryology to prevention of thromboembolism. European Heart Journal, 38(12), 877-887. https://doi.org/10.1093/eurheartj/ehw159

@article{e6e9a8c8c1ca4994a59fb765a205fceb,

title = "The left atrial appendage: From embryology to prevention of thromboembolism",

abstract = "The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure and thrombosis. Here we provide baseline notions on the anatomy and function of the LAA, and then focus on current imaging tools for the identification of anatomical varieties. We also describe pathogenetic mechanisms of LAA thrombosis in AF patients, and examine the available evidence on treatment strategies for LAA thrombosis, including the use of non-vitamin K antagonist oral anticoagulants and interventional approaches.",

keywords = "Anticoagulants, Atrial fibrillation, Left atrial appendage, NOACs, Non-Vitamin K antagonist oral anticoagulants, Occlusion devices, Stroke, Systemic embolism, Thromboembolism",

author = "Giuseppe Patti and Vittorio Pengo and Rossella Marcucci and Plinio Cirillo and Giulia Renda and Francesca Santilli and Paolo Calabr{\`o} and \{De Caterina\}, \{Alberto Ranieri\} and Ilaria Cavallari and Elisabetta Ricottini and Parato, \{Vito Maurizio\} and Giacomo Zoppellaro and \{Di Gioia\}, Giuseppe and Pietro Sedati and Vincenzo Cicchitti and Giovanni Dav{\`i} and Enrica Golia and Ivana Pariggiano and Paola Simeone and Rosanna Abbate and Domenico Prisco and Marco Zimarino and Francesco Sofi and Felicita Andreotti",

note = "Publisher Copyright: {\textcopyright} 2017 The Author.",

year = "2017",

month = mar,

day = "21",

doi = "10.1093/eurheartj/ehw159",

language = "English",

volume = "38",

pages = "877--887",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

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Patti, G, Pengo, V, Marcucci, R, Cirillo, P, Renda, G, Santilli, F, Calabrò, P, De Caterina, AR, Cavallari, I, Ricottini, E, Parato, VM, Zoppellaro, G, Di Gioia, G, Sedati, P, Cicchitti, V, Davì, G, Golia, E, Pariggiano, I, Simeone, P, Abbate, R, Prisco, D, Zimarino, M, Sofi, F & Andreotti, F 2017, 'The left atrial appendage: From embryology to prevention of thromboembolism', European Heart Journal, vol. 38, no. 12, pp. 877-887. https://doi.org/10.1093/eurheartj/ehw159

TY - JOUR

T1 - The left atrial appendage

T2 - From embryology to prevention of thromboembolism

AU - Patti, Giuseppe

AU - Pengo, Vittorio

AU - Marcucci, Rossella

AU - Cirillo, Plinio

AU - Renda, Giulia

AU - Santilli, Francesca

AU - Calabrò, Paolo

AU - De Caterina, Alberto Ranieri

AU - Cavallari, Ilaria

AU - Ricottini, Elisabetta

AU - Parato, Vito Maurizio

AU - Zoppellaro, Giacomo

AU - Di Gioia, Giuseppe

AU - Sedati, Pietro

AU - Cicchitti, Vincenzo

AU - Davì, Giovanni

AU - Golia, Enrica

AU - Pariggiano, Ivana

AU - Simeone, Paola

AU - Abbate, Rosanna

AU - Prisco, Domenico

AU - Zimarino, Marco

AU - Sofi, Francesco

AU - Andreotti, Felicita

PY - 2017/3/21

Y1 - 2017/3/21

N2 - The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure and thrombosis. Here we provide baseline notions on the anatomy and function of the LAA, and then focus on current imaging tools for the identification of anatomical varieties. We also describe pathogenetic mechanisms of LAA thrombosis in AF patients, and examine the available evidence on treatment strategies for LAA thrombosis, including the use of non-vitamin K antagonist oral anticoagulants and interventional approaches.

AB - The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure and thrombosis. Here we provide baseline notions on the anatomy and function of the LAA, and then focus on current imaging tools for the identification of anatomical varieties. We also describe pathogenetic mechanisms of LAA thrombosis in AF patients, and examine the available evidence on treatment strategies for LAA thrombosis, including the use of non-vitamin K antagonist oral anticoagulants and interventional approaches.

KW - Anticoagulants

KW - Atrial fibrillation

KW - Left atrial appendage

KW - NOACs

KW - Non-Vitamin K antagonist oral anticoagulants

KW - Occlusion devices

KW - Stroke

KW - Systemic embolism

KW - Thromboembolism

UR - https://www.scopus.com/pages/publications/85019198737

U2 - 10.1093/eurheartj/ehw159

DO - 10.1093/eurheartj/ehw159

M3 - Review article

SN - 0195-668X

VL - 38

SP - 877

EP - 887

JO - European Heart Journal

JF - European Heart Journal

IS - 12

ER -

The left atrial appendage: From embryology to prevention of thromboembolism

Abstract

Keywords

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