The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

Roberto Licordari; Alessandro Sticchi; Filippo Mancuso; Alessandro Caracciolo; Saverio Muscoli; Fortunato Iacovelli; Rossella Ruggiero; Alessandra Scoccia; Valeria Cammalleri; Marco Pavani; Marco Loffi; Domenico Scordino; Jayme Ferro; Andrea Rognoni; Andrea Buono; Stefano Nava; Stefano Albani; Iginio Colaiori; Filippo Zilio; Marco Borghesi; Valentina Regazzoni; Stefano Benenati; Fabio Pescetelli; Vincenzo De Marzo; Antonioa Mannarini; Francesco Spione; Doronzo Baldassarre; Michele De Benedictis; Roberto Bonmassari; Gian Battista Danzi; Mario Galli; Alfonso Ielasi; Giuseppe Musumeci; Fabrizio Tomai; Vincenzo Pasceri; Italo Porto; Giuseppe Patti; Gianluca Campo; Antonio Colombo; Antonio Micari; Francesco Giannini; Francesco Costa

doi:10.3390/jcm11102926

The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

Roberto Licordari
, Alessandro Sticchi
, Filippo Mancuso
, Alessandro Caracciolo
, Saverio Muscoli
, Fortunato Iacovelli
, Rossella Ruggiero
, Alessandra Scoccia
, Valeria Cammalleri
, Marco Pavani
, Marco Loffi
, Domenico Scordino
, Jayme Ferro
, Andrea Rognoni
, Andrea Buono
, Stefano Nava
, Stefano Albani
, Iginio Colaiori
, Filippo Zilio
, Marco Borghesi

Valentina Regazzoni, Stefano Benenati, Fabio Pescetelli, Vincenzo De Marzo, Antonioa Mannarini, Francesco Spione, Doronzo Baldassarre, Michele De Benedictis, Roberto Bonmassari, Gian Battista Danzi, Mario Galli, Alfonso Ielasi, Giuseppe Musumeci, Fabrizio Tomai, Vincenzo Pasceri, Italo Porto, Giuseppe Patti, Gianluca Campo, Antonio Colombo, Antonio Micari, Francesco Giannini, Francesco Costa

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.

Original language	English
Article number	2926
Journal	Journal of Clinical Medicine
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/jcm11102926
Publication status	Published - 1 May 2022
Externally published	Yes

Keywords

COVID-19
acute coronary syndrome (ACS)
bleeding
in-hospital outcomes
myocardial infarction (MI)

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10.3390/jcm11102926

Cite this

Licordari, R., Sticchi, A., Mancuso, F., Caracciolo, A., Muscoli, S., Iacovelli, F., Ruggiero, R., Scoccia, A., Cammalleri, V., Pavani, M., Loffi, M., Scordino, D., Ferro, J., Rognoni, A., Buono, A., Nava, S., Albani, S., Colaiori, I., Zilio, F., ... Costa, F. (2022). The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic. Journal of Clinical Medicine, 11(10), Article 2926. https://doi.org/10.3390/jcm11102926

@article{cefac89f0da448e5b55a51f2432de11c,

title = "The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic",

abstract = "Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March{\textendash}April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.",

keywords = "COVID-19, acute coronary syndrome (ACS), bleeding, in-hospital outcomes, myocardial infarction (MI)",

author = "Roberto Licordari and Alessandro Sticchi and Filippo Mancuso and Alessandro Caracciolo and Saverio Muscoli and Fortunato Iacovelli and Rossella Ruggiero and Alessandra Scoccia and Valeria Cammalleri and Marco Pavani and Marco Loffi and Domenico Scordino and Jayme Ferro and Andrea Rognoni and Andrea Buono and Stefano Nava and Stefano Albani and Iginio Colaiori and Filippo Zilio and Marco Borghesi and Valentina Regazzoni and Stefano Benenati and Fabio Pescetelli and \{De Marzo\}, Vincenzo and Antonioa Mannarini and Francesco Spione and Doronzo Baldassarre and \{De Benedictis\}, Michele and Roberto Bonmassari and Danzi, \{Gian Battista\} and Mario Galli and Alfonso Ielasi and Giuseppe Musumeci and Fabrizio Tomai and Vincenzo Pasceri and Italo Porto and Giuseppe Patti and Gianluca Campo and Antonio Colombo and Antonio Micari and Francesco Giannini and Francesco Costa",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "1",

doi = "10.3390/jcm11102926",

language = "English",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

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Licordari, R, Sticchi, A, Mancuso, F, Caracciolo, A, Muscoli, S, Iacovelli, F, Ruggiero, R, Scoccia, A, Cammalleri, V, Pavani, M, Loffi, M, Scordino, D, Ferro, J, Rognoni, A, Buono, A, Nava, S, Albani, S, Colaiori, I, Zilio, F, Borghesi, M, Regazzoni, V, Benenati, S, Pescetelli, F, De Marzo, V, Mannarini, A, Spione, F, Baldassarre, D, De Benedictis, M, Bonmassari, R, Danzi, GB, Galli, M, Ielasi, A, Musumeci, G, Tomai, F, Pasceri, V, Porto, I, Patti, G, Campo, G, Colombo, A, Micari, A, Giannini, F & Costa, F 2022, 'The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic', Journal of Clinical Medicine, vol. 11, no. 10, 2926. https://doi.org/10.3390/jcm11102926

TY - JOUR

T1 - The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

AU - Licordari, Roberto

AU - Sticchi, Alessandro

AU - Mancuso, Filippo

AU - Caracciolo, Alessandro

AU - Muscoli, Saverio

AU - Iacovelli, Fortunato

AU - Ruggiero, Rossella

AU - Scoccia, Alessandra

AU - Cammalleri, Valeria

AU - Pavani, Marco

AU - Loffi, Marco

AU - Scordino, Domenico

AU - Ferro, Jayme

AU - Rognoni, Andrea

AU - Buono, Andrea

AU - Nava, Stefano

AU - Albani, Stefano

AU - Colaiori, Iginio

AU - Zilio, Filippo

AU - Borghesi, Marco

AU - Regazzoni, Valentina

AU - Benenati, Stefano

AU - Pescetelli, Fabio

AU - De Marzo, Vincenzo

AU - Mannarini, Antonioa

AU - Spione, Francesco

AU - Baldassarre, Doronzo

AU - De Benedictis, Michele

AU - Bonmassari, Roberto

AU - Danzi, Gian Battista

AU - Galli, Mario

AU - Ielasi, Alfonso

AU - Musumeci, Giuseppe

AU - Tomai, Fabrizio

AU - Pasceri, Vincenzo

AU - Porto, Italo

AU - Patti, Giuseppe

AU - Campo, Gianluca

AU - Colombo, Antonio

AU - Micari, Antonio

AU - Giannini, Francesco

AU - Costa, Francesco

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.

AB - Background: The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS). Aim: to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic. Methods: We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March–April 2020) and in the same period in the previous two years. Results: The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic. Conclusions: the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.

KW - COVID-19

KW - acute coronary syndrome (ACS)

KW - bleeding

KW - in-hospital outcomes

KW - myocardial infarction (MI)

UR - https://www.scopus.com/pages/publications/85130307175

U2 - 10.3390/jcm11102926

DO - 10.3390/jcm11102926

M3 - Article

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 10

M1 - 2926

ER -

The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic

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Keywords

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