The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Flavio Moroni; Grazia Lombardi; Gloriano Moneti; Caterina Aldinio

doi:10.1016/0304-3940(84)90385-9

The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Flavio Moroni
, Grazia Lombardi
, Gloriano Moneti
, Caterina Aldinio

Research output: Contribution to journal › Article › peer-review

Abstract

The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

Original language	English
Pages (from-to)	51-55
Number of pages	5
Journal	Neuroscience Letters
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(84)90385-9
Publication status	Published - 1 Jun 1984
Externally published	Yes

Keywords

aging
development
excitotoxins
guinea pig
mass fragmentography
quinolinic acid
rabbit
rat
tryptophan metabolism

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10.1016/0304-3940(84)90385-9

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title = "The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process",

abstract = "The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50\% of 30-month-old rats.",

keywords = "aging, development, excitotoxins, guinea pig, mass fragmentography, quinolinic acid, rabbit, rat, tryptophan metabolism",

author = "Flavio Moroni and Grazia Lombardi and Gloriano Moneti and Caterina Aldinio",

note = "Funding Information: This work was supported by grants from CNR and from the University of Firenze. We wish to thank G. Bucelli for his expert technical assistance and the Italian Study Group of Brain Aging for supplying the rats.",

year = "1984",

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doi = "10.1016/0304-3940(84)90385-9",

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T1 - The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

AU - Moroni, Flavio

AU - Lombardi, Grazia

AU - Moneti, Gloriano

AU - Aldinio, Caterina

N1 - Funding Information: This work was supported by grants from CNR and from the University of Firenze. We wish to thank G. Bucelli for his expert technical assistance and the Italian Study Group of Brain Aging for supplying the rats.

PY - 1984/6/1

Y1 - 1984/6/1

N2 - The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

AB - The distribution of the excitotoxin quinolinic acid (QUIN) has been evaluated in the brains of rabbit, guinea pig and rat, using a mass spectrometric method. Furthermore, the cortical content of this molecule has been measured during the development and the aging of the rat. The cortex contained the highest concentration of QUIN in the three species studied. During the rat development the concentration of this molecule increased and unusually high amounts of it were found in approximately 50% of 30-month-old rats.

KW - aging

KW - development

KW - excitotoxins

KW - guinea pig

KW - mass fragmentography

KW - quinolinic acid

KW - rabbit

KW - rat

KW - tryptophan metabolism

UR - https://www.scopus.com/pages/publications/0021262777

U2 - 10.1016/0304-3940(84)90385-9

DO - 10.1016/0304-3940(84)90385-9

M3 - Article

SN - 0304-3940

VL - 47

SP - 51

EP - 55

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

Abstract

Keywords

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