The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Luigi Molinengo; Anna Fundarò; Marco Orsetti

doi:10.1016/0091-3057(89)90085-3

The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Luigi Molinengo, Anna Fundarò, Marco Orsetti

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

Original language	English
Pages (from-to)	1075-1077
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(89)90085-3
Publication status	Published - Apr 1989
Externally published	Yes

Keywords

ACh levels
Atropine
Chronic treatment
Mouse motility

Access to Document

10.1016/0091-3057(89)90085-3

Cite this

@article{6e7925b9f7264a4c960dffc72ff71476,

title = "The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system",

abstract = "Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.",

keywords = "ACh levels, Atropine, Chronic treatment, Mouse motility",

author = "Luigi Molinengo and Anna Fundar{\`o} and Marco Orsetti",

year = "1989",

month = apr,

doi = "10.1016/0091-3057(89)90085-3",

language = "English",

volume = "32",

pages = "1075--1077",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

AU - Molinengo, Luigi

AU - Fundarò, Anna

AU - Orsetti, Marco

PY - 1989/4

Y1 - 1989/4

N2 - Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

AB - Changes in mouse motility and CNS cortical and subcortical ACh levels were studied after chronic (20 days) administration of 30, 40 and 60 mg/kg/day atropine. An increase in motility similar to that induced by tropine administration was observed, whereas the ACh levels reduction caused by acute administration was not repeated. These results suggest that changes in mouse motility caused by atropine are not correlated to its modification of ACh levels in the CNS.

KW - ACh levels

KW - Atropine

KW - Chronic treatment

KW - Mouse motility

UR - https://www.scopus.com/pages/publications/0024403151

U2 - 10.1016/0091-3057(89)90085-3

DO - 10.1016/0091-3057(89)90085-3

M3 - Article

SN - 0091-3057

VL - 32

SP - 1075

EP - 1077

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

IS - 4

ER -

The effect of chronic atropine administration on mouse motility and on ACh levels in the central nervous system

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this