The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats

Piero Ruggeri; Claudio Molinari; Andrea Brunori; Carla Emilia Cogo; David A.S.G. Mary; Viviana Picchio; Giovanni Vacca

doi:10.1097/00001756-200112040-00023

The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats

Piero Ruggeri, Claudio Molinari, Andrea Brunori, Carla Emilia Cogo, David A.S.G. Mary, Viviana Picchio, Giovanni Vacca

Department of Sustainable Development and Ecological Transition

Research output: Contribution to journal › Article › peer-review

Abstract

The present investigation was designed to determine the direct effect of insulin on the spontaneous discharge of barosensitive neurones in the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane. Microinjection of 20 nl insulin (10 IU/ml) into NTS decreased the spontaneous discharge of 38 of the 52 units studied (73.1%), and this decrease was augmented by increasing the concentration to 40 IU/ml. Microinjections of insulin vehicle, glucose, hydralazine or phenylephrine did not elicit significant changes in the spontaneous discharge of NTS barosensitive neurones. These results demonstrate that insulin inhibits the spontaneous discharge of barosensitive NTS neurones. They suggest that insulin increases sympathetic nervous activity via a central neural mechanism and may play a role in the modulation of cardiovascular information within the NTS.

Original language	English
Pages (from-to)	3719-3722
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	17
DOIs	https://doi.org/10.1097/00001756-200112040-00023
Publication status	Published - 4 Dec 2001

Keywords

Autonomic nervous system
Brain stem
Cardiovascular control
Insulin
Nucleus tractus solitarii

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10.1097/00001756-200112040-00023

Cite this

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title = "The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats",

abstract = "The present investigation was designed to determine the direct effect of insulin on the spontaneous discharge of barosensitive neurones in the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane. Microinjection of 20 nl insulin (10 IU/ml) into NTS decreased the spontaneous discharge of 38 of the 52 units studied (73.1%), and this decrease was augmented by increasing the concentration to 40 IU/ml. Microinjections of insulin vehicle, glucose, hydralazine or phenylephrine did not elicit significant changes in the spontaneous discharge of NTS barosensitive neurones. These results demonstrate that insulin inhibits the spontaneous discharge of barosensitive NTS neurones. They suggest that insulin increases sympathetic nervous activity via a central neural mechanism and may play a role in the modulation of cardiovascular information within the NTS.",

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author = "Piero Ruggeri and Claudio Molinari and Andrea Brunori and Cogo, {Carla Emilia} and Mary, {David A.S.G.} and Viviana Picchio and Giovanni Vacca",

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T1 - The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats

AU - Ruggeri, Piero

AU - Molinari, Claudio

AU - Brunori, Andrea

AU - Cogo, Carla Emilia

AU - Mary, David A.S.G.

AU - Picchio, Viviana

AU - Vacca, Giovanni

PY - 2001/12/4

Y1 - 2001/12/4

N2 - The present investigation was designed to determine the direct effect of insulin on the spontaneous discharge of barosensitive neurones in the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane. Microinjection of 20 nl insulin (10 IU/ml) into NTS decreased the spontaneous discharge of 38 of the 52 units studied (73.1%), and this decrease was augmented by increasing the concentration to 40 IU/ml. Microinjections of insulin vehicle, glucose, hydralazine or phenylephrine did not elicit significant changes in the spontaneous discharge of NTS barosensitive neurones. These results demonstrate that insulin inhibits the spontaneous discharge of barosensitive NTS neurones. They suggest that insulin increases sympathetic nervous activity via a central neural mechanism and may play a role in the modulation of cardiovascular information within the NTS.

AB - The present investigation was designed to determine the direct effect of insulin on the spontaneous discharge of barosensitive neurones in the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane. Microinjection of 20 nl insulin (10 IU/ml) into NTS decreased the spontaneous discharge of 38 of the 52 units studied (73.1%), and this decrease was augmented by increasing the concentration to 40 IU/ml. Microinjections of insulin vehicle, glucose, hydralazine or phenylephrine did not elicit significant changes in the spontaneous discharge of NTS barosensitive neurones. These results demonstrate that insulin inhibits the spontaneous discharge of barosensitive NTS neurones. They suggest that insulin increases sympathetic nervous activity via a central neural mechanism and may play a role in the modulation of cardiovascular information within the NTS.

KW - Autonomic nervous system

KW - Brain stem

KW - Cardiovascular control

KW - Insulin

KW - Nucleus tractus solitarii

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DO - 10.1097/00001756-200112040-00023

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SN - 0959-4965

VL - 12

SP - 3719

EP - 3722

JO - NeuroReport

JF - NeuroReport

IS - 17

ER -

The direct effect of insulin on barosensitive neurones in the nucleus tractus solitarii of rats

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Keywords

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