The Dermabond Prineo Skin Closure System: Benefits and Complications

Objective: The Dermabond™ Prineo™ Skin Closure System (DP; Ethicon, Somerville, NJ) combines the effectiveness of cyanoacrylate with a self-adhering mesh. DP is used for orthopedic surgery, abdominoplasty, excisional body-contouring procedures, mastopexy, reduction mammoplasty, spine surgery, and obstetrics. Many studies compared DP-type systems with conventional wound-closure methods and found numerous advantages and some complications for the newer system. Methods: This review covers 22 studies reporting side-effects of DP or comparing this skin-closure system with others. Results: Superficial- or deep-wound complications, surgical-site infections, cellulitis, delayed wound healing, dehiscence, allergic contact dermatitis, prolonged discharge from wounds, or necrosis were the main side-effects reported. Conclusions: DP is safe, according to various studies. It has many advantages, such as cost and operating-time reduction, better cosmetic results, and-more-hygienic management of wounds. Several studies claim that there are no significant differences from conventional wound closure in terms of complications. However, there is a potential risk for a type IV hypersensitivity reaction, which is one of the most-important complications related to the DP-type skin-closure system. More research is needed to analyze the adverse outcomes thoroughly, plus analyses of costs, operating times, and cosmetic results of various types of wound-closure system, including this one, to and tailor the best choice of wound closure for each patient following surgery.