The chemokine system in diverse forms of macrophage activation and polarization

Alberto Mantovani; Antonio Sica; Silvano Sozzani; Paola Allavena; Annunciata Vecchi; Massimo Locati

doi:10.1016/j.it.2004.09.015

The chemokine system in diverse forms of macrophage activation and polarization

Alberto Mantovani
, Antonio Sica
, Silvano Sozzani
, Paola Allavena
, Annunciata Vecchi
, Massimo Locati

Research output: Contribution to journal › Review article › peer-review

Abstract

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

Original language	English
Pages (from-to)	677-686
Number of pages	10
Journal	Trends in Immunology
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2004.09.015
Publication status	Published - Dec 2004
Externally published	Yes

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10.1016/j.it.2004.09.015

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title = "The chemokine system in diverse forms of macrophage activation and polarization",

abstract = "Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.",

author = "Alberto Mantovani and Antonio Sica and Silvano Sozzani and Paola Allavena and Annunciata Vecchi and Massimo Locati",

note = "Funding Information: This work was supported by the Italian Association for Cancer Research, MIUR (FIRB, COFIN and CNR funding), Fondo Interno per la Ricerca Scientifica e Tecnologica (FIRST), Ministero della Salute and European Commission.",

year = "2004",

month = dec,

doi = "10.1016/j.it.2004.09.015",

language = "English",

volume = "25",

pages = "677--686",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - The chemokine system in diverse forms of macrophage activation and polarization

AU - Mantovani, Alberto

AU - Sica, Antonio

AU - Sozzani, Silvano

AU - Allavena, Paola

AU - Vecchi, Annunciata

AU - Locati, Massimo

N1 - Funding Information: This work was supported by the Italian Association for Cancer Research, MIUR (FIRB, COFIN and CNR funding), Fondo Interno per la Ricerca Scientifica e Tecnologica (FIRST), Ministero della Salute and European Commission.

PY - 2004/12

Y1 - 2004/12

N2 - Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

AB - Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1, M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

UR - https://www.scopus.com/pages/publications/7644231561

U2 - 10.1016/j.it.2004.09.015

DO - 10.1016/j.it.2004.09.015

M3 - Review article

SN - 1471-4906

VL - 25

SP - 677

EP - 686

JO - Trends in Immunology

JF - Trends in Immunology

IS - 12

ER -

The chemokine system in diverse forms of macrophage activation and polarization

Abstract

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