TY - JOUR
T1 - The antianaphylactic action of histamine H2‐receptor agonists in the guinea‐pig isolated heart
AU - Blandina, P.
AU - Brunelleschi, Sandra
AU - Fantozzi, R.
AU - Giannella, Eliana
AU - Mannaioni, P. F.
AU - Masini, Emanuela
PY - 1987/3
Y1 - 1987/3
N2 - The effects of histamine and of H1‐and H2‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H2‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H1‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H2‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society
AB - The effects of histamine and of H1‐and H2‐receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea‐pigs. Histamine and H2‐receptor agonists (dimaprit, impromidine) dose‐dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. Nordimaprit and the selective H1‐receptor agonist 2‐pyridyl‐ethyl‐amine (2‐PEA) did not modify the patterns of cardiac anaphylaxis. The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. The H2‐receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2‐receptors in cardiac anaphylaxis. 1987 British Pharmacological Society
UR - http://www.scopus.com/inward/record.url?scp=0023114674&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.1987.tb11195.x
DO - 10.1111/j.1476-5381.1987.tb11195.x
M3 - Article
SN - 0007-1188
VL - 90
SP - 459
EP - 466
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 3
ER -