Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging

Marco Krengli; Barbara Cannillo; Lucia Turri; Paolo Bagnasacco; Laura Berretta; Teresa Ferrara; Mario Galliano; Sergio Gribaudo; Antonella Melano; Fernando Munoz; Piera Sciacero; Vassiliki Tseroni; Maria Chiara Bassi; Marco Brambilla; Eugenio Inglese

doi:10.1177/153303461000900408

Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging

Marco Krengli
, Barbara Cannillo
, Lucia Turri
, Paolo Bagnasacco
, Laura Berretta
, Teresa Ferrara
, Mario Galliano
, Sergio Gribaudo
, Antonella Melano
, Fernando Munoz
, Piera Sciacero
, Vassiliki Tseroni
, Maria Chiara Bassi
, Marco Brambilla
, Eugenio Inglese

Research output: Contribution to journal › Article › peer-review

Abstract

To analyze the inter-observer variability and the potential impact of ¹⁸F-fluorodeoxyglucose FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coef-ficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc ± 20.4 cc in case A and 119 cc ± 35.7 cc in case B. Mean CTV was 723 cc ± 147.5 cc in case A and 739 cc ± 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.

Original language	English
Pages (from-to)	393-398
Number of pages	6
Journal	Technology in Cancer Research and Treatment
Volume	9
Issue number	4
DOIs	https://doi.org/10.1177/153303461000900408
Publication status	Published - Aug 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Observer variability
PET/CT
Radiotherapy
Rectal cancer
Treatment planning

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10.1177/153303461000900408

Cite this

Krengli, M., Cannillo, B., Turri, L., Bagnasacco, P., Berretta, L., Ferrara, T., Galliano, M., Gribaudo, S., Melano, A., Munoz, F., Sciacero, P., Tseroni, V., Bassi, M. C., Brambilla, M., & Inglese, E. (2010). Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging. Technology in Cancer Research and Treatment, 9(4), 393-398. https://doi.org/10.1177/153303461000900408

@article{24595d4a76cc43be9c20bb62d4a670b5,

title = "Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging",

abstract = "To analyze the inter-observer variability and the potential impact of 18F-fluorodeoxyglucose FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coef-ficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc ± 20.4 cc in case A and 119 cc ± 35.7 cc in case B. Mean CTV was 723 cc ± 147.5 cc in case A and 739 cc ± 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.",

keywords = "Observer variability, PET/CT, Radiotherapy, Rectal cancer, Treatment planning",

author = "Marco Krengli and Barbara Cannillo and Lucia Turri and Paolo Bagnasacco and Laura Berretta and Teresa Ferrara and Mario Galliano and Sergio Gribaudo and Antonella Melano and Fernando Munoz and Piera Sciacero and Vassiliki Tseroni and Bassi, \{Maria Chiara\} and Marco Brambilla and Eugenio Inglese",

year = "2010",

month = aug,

doi = "10.1177/153303461000900408",

language = "English",

volume = "9",

pages = "393--398",

journal = "Technology in Cancer Research and Treatment",

issn = "1533-0346",

publisher = "SAGE Publications Inc.",

number = "4",

}

Krengli, M, Cannillo, B, Turri, L, Bagnasacco, P, Berretta, L, Ferrara, T, Galliano, M, Gribaudo, S, Melano, A, Munoz, F, Sciacero, P, Tseroni, V, Bassi, MC, Brambilla, M & Inglese, E 2010, 'Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging', Technology in Cancer Research and Treatment, vol. 9, no. 4, pp. 393-398. https://doi.org/10.1177/153303461000900408

TY - JOUR

T1 - Target volume delineation for preoperative radiotherapy of rectal cancer

T2 - Inter-observer variability and potential impact of FDG-PET/CT imaging

AU - Krengli, Marco

AU - Cannillo, Barbara

AU - Turri, Lucia

AU - Bagnasacco, Paolo

AU - Berretta, Laura

AU - Ferrara, Teresa

AU - Galliano, Mario

AU - Gribaudo, Sergio

AU - Melano, Antonella

AU - Munoz, Fernando

AU - Sciacero, Piera

AU - Tseroni, Vassiliki

AU - Bassi, Maria Chiara

AU - Brambilla, Marco

AU - Inglese, Eugenio

PY - 2010/8

Y1 - 2010/8

N2 - To analyze the inter-observer variability and the potential impact of 18F-fluorodeoxyglucose FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coef-ficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc ± 20.4 cc in case A and 119 cc ± 35.7 cc in case B. Mean CTV was 723 cc ± 147.5 cc in case A and 739 cc ± 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.

AB - To analyze the inter-observer variability and the potential impact of 18F-fluorodeoxyglucose FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coef-ficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc ± 20.4 cc in case A and 119 cc ± 35.7 cc in case B. Mean CTV was 723 cc ± 147.5 cc in case A and 739 cc ± 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.

KW - Observer variability

KW - PET/CT

KW - Radiotherapy

KW - Rectal cancer

KW - Treatment planning

UR - https://www.scopus.com/pages/publications/77956523690

U2 - 10.1177/153303461000900408

DO - 10.1177/153303461000900408

M3 - Article

SN - 1533-0346

VL - 9

SP - 393

EP - 398

JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

IS - 4

ER -

Target volume delineation for preoperative radiotherapy of rectal cancer: Inter-observer variability and potential impact of FDG-PET/CT imaging

Abstract

UN SDGs

Keywords

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