Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Loretta Lazzarato; Barbara Rolando; Marco L. Lolli; Gian Cesare Tron; Roberta Fruttero; Alberto Gasco; Guido Deleide; Harald L. Guenther

doi:10.1021/jm040830d

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Loretta Lazzarato
, Barbara Rolando
, Marco L. Lolli
, Gian Cesare Tron
, Roberta Fruttero
, Alberto Gasco
, Guido Deleide
, Harald L. Guenther

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of ^99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-κB ligand (RANKL), through a prevalent NO-dependent mechanism.

Original language	English
Pages (from-to)	1322-1329
Number of pages	8
Journal	Journal of Medicinal Chemistry
Volume	48
Issue number	5
DOIs	https://doi.org/10.1021/jm040830d
Publication status	Published - 10 Mar 2005

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10.1021/jm040830d

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abstract = "A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-κB ligand (RANKL), through a prevalent NO-dependent mechanism.",

author = "Loretta Lazzarato and Barbara Rolando and Lolli, \{Marco L.\} and Tron, \{Gian Cesare\} and Roberta Fruttero and Alberto Gasco and Guido Deleide and Guenther, \{Harald L.\}",

year = "2005",

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doi = "10.1021/jm040830d",

language = "English",

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T1 - Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

AU - Lazzarato, Loretta

AU - Rolando, Barbara

AU - Lolli, Marco L.

AU - Tron, Gian Cesare

AU - Fruttero, Roberta

AU - Gasco, Alberto

AU - Deleide, Guido

AU - Guenther, Harald L.

PY - 2005/3/10

Y1 - 2005/3/10

N2 - A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-κB ligand (RANKL), through a prevalent NO-dependent mechanism.

AB - A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-κB ligand (RANKL), through a prevalent NO-dependent mechanism.

UR - https://www.scopus.com/pages/publications/14944365641

U2 - 10.1021/jm040830d

DO - 10.1021/jm040830d

M3 - Article

SN - 0022-2623

VL - 48

SP - 1322

EP - 1329

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 5

ER -

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption

Abstract

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