Synthesis of Disaccharidic Sub-units of a New Series of Heparin Related Oligosaccharides

FERLA B. LA; L. LAY; M. GUERRINI; L. POLETTI; Luigi PANZA

Synthesis of Disaccharidic Sub-units of a New Series of Heparin Related Oligosaccharides

FERLA B. LA
, L. LAY
, M. GUERRINI
, L. POLETTI
, Luigi PANZA

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article

Abstract

The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

Original language	English
Pages (from-to)	9867-9880
Number of pages	14
Journal	Tetrahedron
Volume	55
Publication status	Published - 1999

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@article{e8751433676846d7904205e2711f957f,

title = "Synthesis of Disaccharidic Sub-units of a New Series of Heparin Related Oligosaccharides",

abstract = "The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.",

author = "LA, \{FERLA B.\} and L. LAY and M. GUERRINI and L. POLETTI and Luigi PANZA",

note = "Funding Information: Acknowled\textasciitilde{},ements - We thank ELI (CARENET-2 project, contract ERB-FMRX-CT 96-0025) and MURST (Ministero dell'Universita e della Ricerca Scientifica e Tecnologica) for financial support.",

year = "1999",

language = "English",

volume = "55",

pages = "9867--9880",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Synthesis of Disaccharidic Sub-units of a New Series of Heparin Related Oligosaccharides

AU - LA, FERLA B.

AU - LAY, L.

AU - GUERRINI, M.

AU - POLETTI, L.

AU - PANZA, Luigi

N1 - Funding Information: Acknowled~,ements - We thank ELI (CARENET-2 project, contract ERB-FMRX-CT 96-0025) and MURST (Ministero dell'Universita e della Ricerca Scientifica e Tecnologica) for financial support.

PY - 1999

Y1 - 1999

N2 - The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

AB - The chemical synthesis of disaccharides 1 and 2, useful building-blocks for the preparation of a new series of heparin related oligosaccharides containing the unusual sequence (GlcN-IdoA)(n), is described. In addition, the orthogonality of the protective groups would allow access to a wide array of differently sulfated oligosaccharides. As the simplest members of this new class of oligomer, the synthesis of sulfated disaccharides 3 and 4 fully deprotected is reported.

UR - https://iris.uniupo.it/handle/11579/6663

M3 - Article

SN - 0040-4020

VL - 55

SP - 9867

EP - 9880

JO - Tetrahedron

JF - Tetrahedron

ER -

Synthesis of Disaccharidic Sub-units of a New Series of Heparin Related Oligosaccharides

Abstract

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