Synthesis of building blocks of human milk oligosaccharides. Fucosylated derivatives of the lacto- and neolacto-series

Barbara La Ferla; Davide Prosperi; Luigi Lay; Giovanni Russo; Luigi Panza

doi:10.1016/S0008-6215(02)00164-7

Synthesis of building blocks of human milk oligosaccharides. Fucosylated derivatives of the lacto- and neolacto-series

Barbara La Ferla
, Davide Prosperi
, Luigi Lay
, Giovanni Russo
, Luigi Panza

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of protected fucosylated derivatives of a Galβ(1→3)GlcNAc and of lactosamine Galβ(1→4)GlcNAc building blocks contained in human milk oligosaccharides is described. Both chemical and enzymatic methods have been exploited for selective protection of the disaccharide. Fucosylation of the appropriate derivatives allowed an easy and relatively short access to different products from common precursors.

Original language	English
Pages (from-to)	1333-1342
Number of pages	10
Journal	Carbohydrate Research
Volume	337
Issue number	15
DOIs	https://doi.org/10.1016/S0008-6215(02)00164-7
Publication status	Published - 3 Sept 2002

Keywords

Building block
Human milk
Lewis
Lipases
N-Acetyl lactosamine
Oligosaccharide derivatives, synthesis

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10.1016/S0008-6215(02)00164-7

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title = "Synthesis of building blocks of human milk oligosaccharides. Fucosylated derivatives of the lacto- and neolacto-series",

abstract = "The synthesis of protected fucosylated derivatives of a Galβ(1→3)GlcNAc and of lactosamine Galβ(1→4)GlcNAc building blocks contained in human milk oligosaccharides is described. Both chemical and enzymatic methods have been exploited for selective protection of the disaccharide. Fucosylation of the appropriate derivatives allowed an easy and relatively short access to different products from common precursors.",

keywords = "Building block, Human milk, Lewis, Lipases, N-Acetyl lactosamine, Oligosaccharide derivatives, synthesis",

author = "\{La Ferla\}, Barbara and Davide Prosperi and Luigi Lay and Giovanni Russo and Luigi Panza",

note = "Funding Information: This work was supported by the EU-NOFA project (grant Fair CT973142), MURST (Ministero dell'Universit{\`a} e della Ricerca Scientifica e Tecnologica) and CNR (Consiglio Nazionale delle Ricerche). ",

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doi = "10.1016/S0008-6215(02)00164-7",

language = "English",

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journal = "Carbohydrate Research",

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TY - JOUR

T1 - Synthesis of building blocks of human milk oligosaccharides. Fucosylated derivatives of the lacto- and neolacto-series

AU - La Ferla, Barbara

AU - Prosperi, Davide

AU - Lay, Luigi

AU - Russo, Giovanni

AU - Panza, Luigi

N1 - Funding Information: This work was supported by the EU-NOFA project (grant Fair CT973142), MURST (Ministero dell'Università e della Ricerca Scientifica e Tecnologica) and CNR (Consiglio Nazionale delle Ricerche).

PY - 2002/9/3

Y1 - 2002/9/3

N2 - The synthesis of protected fucosylated derivatives of a Galβ(1→3)GlcNAc and of lactosamine Galβ(1→4)GlcNAc building blocks contained in human milk oligosaccharides is described. Both chemical and enzymatic methods have been exploited for selective protection of the disaccharide. Fucosylation of the appropriate derivatives allowed an easy and relatively short access to different products from common precursors.

AB - The synthesis of protected fucosylated derivatives of a Galβ(1→3)GlcNAc and of lactosamine Galβ(1→4)GlcNAc building blocks contained in human milk oligosaccharides is described. Both chemical and enzymatic methods have been exploited for selective protection of the disaccharide. Fucosylation of the appropriate derivatives allowed an easy and relatively short access to different products from common precursors.

KW - Building block

KW - Human milk

KW - Lewis

KW - Lipases

KW - N-Acetyl lactosamine

KW - Oligosaccharide derivatives, synthesis

UR - https://www.scopus.com/pages/publications/0037014993

U2 - 10.1016/S0008-6215(02)00164-7

DO - 10.1016/S0008-6215(02)00164-7

M3 - Article

SN - 0008-6215

VL - 337

SP - 1333

EP - 1342

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 15

ER -

Synthesis of building blocks of human milk oligosaccharides. Fucosylated derivatives of the lacto- and neolacto-series

Abstract

Keywords

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