Synthesis of a glycosylated ortho-carboranyl amino acid

Christian Thimon; Luigi Panza; Christophe Morin

doi:10.1055/s-2003-40834

Synthesis of a glycosylated ortho-carboranyl amino acid

Christian Thimon
, Luigi Panza
, Christophe Morin

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The preparation of an ortho-carborane derivative bearing both carbohydrate and amino acid substituents is presented; opening of a glucofuranuro-γ-lactone derivative with propargylamines, cycloaddition of decaborane to an acetylenic bond and amidation with a N-Fmoc-glutamate derivative are the key-steps in this synthesis.

Original language	English
Pages (from-to)	1399-1402
Number of pages	4
Journal	Synlett
Issue number	10
DOIs	https://doi.org/10.1055/s-2003-40834
Publication status	Published - 2003

Keywords

Amino acids
Boron
Carbohydrates
Carboranes
Cyclo-additions

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10.1055/s-2003-40834

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title = "Synthesis of a glycosylated ortho-carboranyl amino acid",

abstract = "The preparation of an ortho-carborane derivative bearing both carbohydrate and amino acid substituents is presented; opening of a glucofuranuro-γ-lactone derivative with propargylamines, cycloaddition of decaborane to an acetylenic bond and amidation with a N-Fmoc-glutamate derivative are the key-steps in this synthesis.",

keywords = "Amino acids, Boron, Carbohydrates, Carboranes, Cyclo-additions",

author = "Christian Thimon and Luigi Panza and Christophe Morin",

year = "2003",

doi = "10.1055/s-2003-40834",

language = "English",

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AU - Thimon, Christian

AU - Panza, Luigi

AU - Morin, Christophe

PY - 2003

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N2 - The preparation of an ortho-carborane derivative bearing both carbohydrate and amino acid substituents is presented; opening of a glucofuranuro-γ-lactone derivative with propargylamines, cycloaddition of decaborane to an acetylenic bond and amidation with a N-Fmoc-glutamate derivative are the key-steps in this synthesis.

AB - The preparation of an ortho-carborane derivative bearing both carbohydrate and amino acid substituents is presented; opening of a glucofuranuro-γ-lactone derivative with propargylamines, cycloaddition of decaborane to an acetylenic bond and amidation with a N-Fmoc-glutamate derivative are the key-steps in this synthesis.

KW - Amino acids

KW - Boron

KW - Carbohydrates

KW - Carboranes

KW - Cyclo-additions

UR - https://www.scopus.com/pages/publications/0042697203

U2 - 10.1055/s-2003-40834

DO - 10.1055/s-2003-40834

M3 - Article

SN - 0936-5214

SP - 1399

EP - 1402

JO - Synlett

JF - Synlett

IS - 10

ER -

Synthesis of a glycosylated ortho-carboranyl amino acid

Abstract

Keywords

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