Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

Lorenzo Tei; Zsolt Baranyai; Mauro Botta; Laura Piscopo; Silvio Aime; Giovanni B. Giovenzana

doi:10.1039/b804195d

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

Lorenzo Tei, Zsolt Baranyai, Mauro Botta, Laura Piscopo, Silvio Aime, Giovanni B. Giovenzana

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Abstract

The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.

Original language	English
Pages (from-to)	2361-2368
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	13
DOIs	https://doi.org/10.1039/b804195d
Publication status	Published - 2008

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abstract = "The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.",

author = "Lorenzo Tei and Zsolt Baranyai and Mauro Botta and Laura Piscopo and Silvio Aime and Giovenzana, {Giovanni B.}",

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AU - Tei, Lorenzo

AU - Baranyai, Zsolt

AU - Botta, Mauro

AU - Piscopo, Laura

AU - Aime, Silvio

AU - Giovenzana, Giovanni B.

PY - 2008

Y1 - 2008

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AB - The synthesis of a new series of EGTA (ethyleneglycol-bis(2- aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.

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U2 - 10.1039/b804195d

DO - 10.1039/b804195d

M3 - Article

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SP - 2361

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 13

ER -

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

Abstract

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