Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

Kenneth Ssebambulidde; Ivan Segawa; Eva Laker; Mohammed Lamorde; Barbara Castelnouvo; Noeline Nakasujja; Andrea CALCAGNO

doi:10.1093/omcr/omy132

Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

Kenneth Ssebambulidde
, Ivan Segawa
, Eva Laker
, Mohammed Lamorde
, Barbara Castelnouvo
, Noeline Nakasujja
, Andrea CALCAGNO

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	Oxford Medical Case Reports
Volume	2019
Issue number	2
DOIs	https://doi.org/10.1093/omcr/omy132
Publication status	Published - 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/omcr/omy132

https://hdl.handle.net/11579/216808

Cite this

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title = "Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda",

abstract = "Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.",

author = "Kenneth Ssebambulidde and Ivan Segawa and Eva Laker and Mohammed Lamorde and Barbara Castelnouvo and Noeline Nakasujja and Andrea CALCAGNO",

year = "2019",

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T1 - Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

AU - Ssebambulidde, Kenneth

AU - Segawa, Ivan

AU - Laker, Eva

AU - Lamorde, Mohammed

AU - Castelnouvo, Barbara

AU - Nakasujja, Noeline

AU - CALCAGNO, Andrea

PY - 2019

Y1 - 2019

N2 - Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.

AB - Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.

UR - https://iris.uniupo.it/handle/11579/216808

U2 - 10.1093/omcr/omy132

DO - 10.1093/omcr/omy132

M3 - Article

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VL - 2019

SP - 79

EP - 82

JO - Oxford Medical Case Reports

JF - Oxford Medical Case Reports

IS - 2

ER -

Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda

Abstract

UN SDGs

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