Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992

C. Spix; T. Aareleid; C. Stiller; C. Magnani; P. Kaatsch; J. Michaelis; W. Oberaigner; H. Storm; T. Hakulinen; J. Mace-Lesec'h; G. Chaplain; P. Arveux; N. Raverdy; L. Tryggvadottir; P. Crosignani; E. Conti; M. Vercelli; M. Federico; L. Mangone; V. De Lisi; L. Gafà; R. Tumino; F. Falcini; A. Barchielli; J. Pawlega; J. Rachtan; M. Bielska-Lasota; Z. Wronkowski; A. Obsitnikova; I. Plesko; V. Pompe-Kirn; I. Izarzugaza; P. Viladiu; C. Martinez-Garcia; I. Garau; E. Ardanaz; J. Galceran; T. Möller; C. Bouchardy; L. Raymond; J. W. Coebergh; R. Black; A. Gould

doi:10.1016/S0959-8049(01)00003-X

Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992

C. Spix
, T. Aareleid
, C. Stiller
, C. Magnani
, P. Kaatsch
, J. Michaelis
, W. Oberaigner
, H. Storm
, T. Hakulinen
, J. Mace-Lesec'h
, G. Chaplain
, P. Arveux
, N. Raverdy
, L. Tryggvadottir
, P. Crosignani
, E. Conti
, M. Vercelli
, M. Federico
, L. Mangone
, V. De Lisi

L. Gafà, R. Tumino, F. Falcini, A. Barchielli, J. Pawlega, J. Rachtan, M. Bielska-Lasota, Z. Wronkowski, A. Obsitnikova, I. Plesko, V. Pompe-Kirn, I. Izarzugaza, P. Viladiu, C. Martinez-Garcia, I. Garau, E. Ardanaz, J. Galceran, T. Möller, C. Bouchardy, L. Raymond, J. W. Coebergh, R. Black, A. Gould

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroblastoma is one of the most common solid cancers in children. We present the data collected for the EUROCARE II study, describing survival patterns for children diagnosed in Europe 1985-1989 in detail, and exploring time trends from 1978 to 1992. On average, the mean 5-year survival rate was considerably higher in infants (79%) compared with older children (30-33%). The risk of death has dropped by 37% from 1978-1981 to 1990-1992. There is a pronounced difference between countries, with Scotland and England and Wales having two of the lowest survival rates (28% (95% confidence interval (CI) 14-48) and 36% (95% CI 31-41) 5-year survival rates, respectively). The survival rates in France, Germany and Italy (48-66% 5-year survival rate) were among the highest. This pattern corresponds to the incidence rates for these countries. It can be assumed that in neuroblastoma, both incidence and survival are related to the frequency of diagnosing asymptomatic cases with good prognosis among infants. However, one cannot ignore possible intercountry differences in the effectiveness of therapy.

Original language	English
Pages (from-to)	722-729
Number of pages	8
Journal	European Journal of Cancer
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/S0959-8049(01)00003-X
Publication status	Published - 1 Jan 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Europe
Neuroblastoma
Survival rates
Time trends in survival

Access to Document

10.1016/S0959-8049(01)00003-X

Cite this

Spix, C., Aareleid, T., Stiller, C., Magnani, C., Kaatsch, P., Michaelis, J., Oberaigner, W., Storm, H., Hakulinen, T., Mace-Lesec'h, J., Chaplain, G., Arveux, P., Raverdy, N., Tryggvadottir, L., Crosignani, P., Conti, E., Vercelli, M., Federico, M., Mangone, L., ... Gould, A. (2001). Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992. European Journal of Cancer, 37(6), 722-729. https://doi.org/10.1016/S0959-8049(01)00003-X

@article{a3d3bf4f2c17472186cecfcfbbe6228c,

title = "Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992",

abstract = "Neuroblastoma is one of the most common solid cancers in children. We present the data collected for the EUROCARE II study, describing survival patterns for children diagnosed in Europe 1985-1989 in detail, and exploring time trends from 1978 to 1992. On average, the mean 5-year survival rate was considerably higher in infants (79\%) compared with older children (30-33\%). The risk of death has dropped by 37\% from 1978-1981 to 1990-1992. There is a pronounced difference between countries, with Scotland and England and Wales having two of the lowest survival rates (28\% (95\% confidence interval (CI) 14-48) and 36\% (95\% CI 31-41) 5-year survival rates, respectively). The survival rates in France, Germany and Italy (48-66\% 5-year survival rate) were among the highest. This pattern corresponds to the incidence rates for these countries. It can be assumed that in neuroblastoma, both incidence and survival are related to the frequency of diagnosing asymptomatic cases with good prognosis among infants. However, one cannot ignore possible intercountry differences in the effectiveness of therapy.",

keywords = "Europe, Neuroblastoma, Survival rates, Time trends in survival",

author = "C. Spix and T. Aareleid and C. Stiller and C. Magnani and P. Kaatsch and J. Michaelis and W. Oberaigner and H. Storm and T. Hakulinen and J. Mace-Lesec'h and G. Chaplain and P. Arveux and N. Raverdy and L. Tryggvadottir and P. Crosignani and E. Conti and M. Vercelli and M. Federico and L. Mangone and \{De Lisi\}, V. and L. Gaf{\`a} and R. Tumino and F. Falcini and A. Barchielli and J. Pawlega and J. Rachtan and M. Bielska-Lasota and Z. Wronkowski and A. Obsitnikova and I. Plesko and V. Pompe-Kirn and I. Izarzugaza and P. Viladiu and C. Martinez-Garcia and I. Garau and E. Ardanaz and J. Galceran and T. M{\"o}ller and C. Bouchardy and L. Raymond and Coebergh, \{J. W.\} and R. Black and A. Gould",

note = "Funding Information: The EUROCARE II study was financed through the BIOMED programme of the European Union. The Childhood Cancer Research Group is supported by the Departments of Health for England, Scotland and Wales. The authors are grateful to the registries for collecting data and completing active follow up. We thank Riccardo Capocaccia, Rome, for providing data and tables. We thank Gemma Gatta, Rome, and Frank Berthold, Cologne, for valuable comments and input.",

year = "2001",

month = jan,

day = "1",

doi = "10.1016/S0959-8049(01)00003-X",

language = "English",

volume = "37",

pages = "722--729",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

number = "6",

}

Spix, C, Aareleid, T, Stiller, C, Magnani, C, Kaatsch, P, Michaelis, J, Oberaigner, W, Storm, H, Hakulinen, T, Mace-Lesec'h, J, Chaplain, G, Arveux, P, Raverdy, N, Tryggvadottir, L, Crosignani, P, Conti, E, Vercelli, M, Federico, M, Mangone, L, De Lisi, V, Gafà, L, Tumino, R, Falcini, F, Barchielli, A, Pawlega, J, Rachtan, J, Bielska-Lasota, M, Wronkowski, Z, Obsitnikova, A, Plesko, I, Pompe-Kirn, V, Izarzugaza, I, Viladiu, P, Martinez-Garcia, C, Garau, I, Ardanaz, E, Galceran, J, Möller, T, Bouchardy, C, Raymond, L, Coebergh, JW, Black, R & Gould, A 2001, 'Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992', European Journal of Cancer, vol. 37, no. 6, pp. 722-729. https://doi.org/10.1016/S0959-8049(01)00003-X

TY - JOUR

T1 - Survival of children with neuroblastoma

T2 - Time trends and regional differences in Europe, 1978-1992

AU - Spix, C.

AU - Aareleid, T.

AU - Stiller, C.

AU - Magnani, C.

AU - Kaatsch, P.

AU - Michaelis, J.

AU - Oberaigner, W.

AU - Storm, H.

AU - Hakulinen, T.

AU - Mace-Lesec'h, J.

AU - Chaplain, G.

AU - Arveux, P.

AU - Raverdy, N.

AU - Tryggvadottir, L.

AU - Crosignani, P.

AU - Conti, E.

AU - Vercelli, M.

AU - Federico, M.

AU - Mangone, L.

AU - De Lisi, V.

AU - Gafà, L.

AU - Tumino, R.

AU - Falcini, F.

AU - Barchielli, A.

AU - Pawlega, J.

AU - Rachtan, J.

AU - Bielska-Lasota, M.

AU - Wronkowski, Z.

AU - Obsitnikova, A.

AU - Plesko, I.

AU - Pompe-Kirn, V.

AU - Izarzugaza, I.

AU - Viladiu, P.

AU - Martinez-Garcia, C.

AU - Garau, I.

AU - Ardanaz, E.

AU - Galceran, J.

AU - Möller, T.

AU - Bouchardy, C.

AU - Raymond, L.

AU - Coebergh, J. W.

AU - Black, R.

AU - Gould, A.

N1 - Funding Information: The EUROCARE II study was financed through the BIOMED programme of the European Union. The Childhood Cancer Research Group is supported by the Departments of Health for England, Scotland and Wales. The authors are grateful to the registries for collecting data and completing active follow up. We thank Riccardo Capocaccia, Rome, for providing data and tables. We thank Gemma Gatta, Rome, and Frank Berthold, Cologne, for valuable comments and input.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Neuroblastoma is one of the most common solid cancers in children. We present the data collected for the EUROCARE II study, describing survival patterns for children diagnosed in Europe 1985-1989 in detail, and exploring time trends from 1978 to 1992. On average, the mean 5-year survival rate was considerably higher in infants (79%) compared with older children (30-33%). The risk of death has dropped by 37% from 1978-1981 to 1990-1992. There is a pronounced difference between countries, with Scotland and England and Wales having two of the lowest survival rates (28% (95% confidence interval (CI) 14-48) and 36% (95% CI 31-41) 5-year survival rates, respectively). The survival rates in France, Germany and Italy (48-66% 5-year survival rate) were among the highest. This pattern corresponds to the incidence rates for these countries. It can be assumed that in neuroblastoma, both incidence and survival are related to the frequency of diagnosing asymptomatic cases with good prognosis among infants. However, one cannot ignore possible intercountry differences in the effectiveness of therapy.

AB - Neuroblastoma is one of the most common solid cancers in children. We present the data collected for the EUROCARE II study, describing survival patterns for children diagnosed in Europe 1985-1989 in detail, and exploring time trends from 1978 to 1992. On average, the mean 5-year survival rate was considerably higher in infants (79%) compared with older children (30-33%). The risk of death has dropped by 37% from 1978-1981 to 1990-1992. There is a pronounced difference between countries, with Scotland and England and Wales having two of the lowest survival rates (28% (95% confidence interval (CI) 14-48) and 36% (95% CI 31-41) 5-year survival rates, respectively). The survival rates in France, Germany and Italy (48-66% 5-year survival rate) were among the highest. This pattern corresponds to the incidence rates for these countries. It can be assumed that in neuroblastoma, both incidence and survival are related to the frequency of diagnosing asymptomatic cases with good prognosis among infants. However, one cannot ignore possible intercountry differences in the effectiveness of therapy.

KW - Europe

KW - Neuroblastoma

KW - Survival rates

KW - Time trends in survival

UR - https://www.scopus.com/pages/publications/0035044323

U2 - 10.1016/S0959-8049(01)00003-X

DO - 10.1016/S0959-8049(01)00003-X

M3 - Article

SN - 0959-8049

VL - 37

SP - 722

EP - 729

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 6

ER -

Survival of children with neuroblastoma: Time trends and regional differences in Europe, 1978-1992

Abstract

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Keywords

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