Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Andrea Pession; Elisa Dama; Roberto Rondelli; Corrado Magnani; Marisa De Rosa; Franco Locatelli; Franca Fagioli; Riccardo Haupt; Momcilo Jankovic; Benedetto Terracini; Franco Merletti; Guido Pastore

doi:10.1016/j.ejca.2008.03.020

Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Andrea Pession
, Elisa Dama
, Roberto Rondelli
, Corrado Magnani
, Marisa De Rosa
, Franco Locatelli
, Franca Fagioli
, Riccardo Haupt
, Momcilo Jankovic
, Benedetto Terracini
, Franco Merletti
, Guido Pastore

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

Original language	English
Pages (from-to)	1282-1289
Number of pages	8
Journal	European Journal of Cancer
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/j.ejca.2008.03.020
Publication status	Published - Jun 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer registration
Childhood cancer
Gender
Italy
Survival

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10.1016/j.ejca.2008.03.020

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Pession, A., Dama, E., Rondelli, R., Magnani, C., De Rosa, M., Locatelli, F., Fagioli, F., Haupt, R., Jankovic, M., Terracini, B., Merletti, F., & Pastore, G. (2008). Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP). European Journal of Cancer, 44(9), 1282-1289. https://doi.org/10.1016/j.ejca.2008.03.020

@article{fbd93d6db295447a9a181b309729c855,

title = "Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)",

abstract = "We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76\% for lymphoproliferative disorders and 68\% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.",

keywords = "Cancer registration, Childhood cancer, Gender, Italy, Survival",

author = "Andrea Pession and Elisa Dama and Roberto Rondelli and Corrado Magnani and \{De Rosa\}, Marisa and Franco Locatelli and Franca Fagioli and Riccardo Haupt and Momcilo Jankovic and Benedetto Terracini and Franco Merletti and Guido Pastore",

note = "Funding Information: This study was partially supported by the Italian Association for Cancer Research and Compagnia San Paolo/FIRMS. The funding association had no role in the design of this study, the data collection, the analysis and interpretation of the results, or the writing of the manuscript. The authors thank Ms. Assunta Rasulo and Lucia Nonnato for the careful conduct of the follow-up. ",

year = "2008",

month = jun,

doi = "10.1016/j.ejca.2008.03.020",

language = "English",

volume = "44",

pages = "1282--1289",

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Pession, A, Dama, E, Rondelli, R, Magnani, C, De Rosa, M, Locatelli, F, Fagioli, F, Haupt, R, Jankovic, M, Terracini, B, Merletti, F & Pastore, G 2008, 'Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)', European Journal of Cancer, vol. 44, no. 9, pp. 1282-1289. https://doi.org/10.1016/j.ejca.2008.03.020

TY - JOUR

T1 - Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

AU - Pession, Andrea

AU - Dama, Elisa

AU - Rondelli, Roberto

AU - Magnani, Corrado

AU - De Rosa, Marisa

AU - Locatelli, Franco

AU - Fagioli, Franca

AU - Haupt, Riccardo

AU - Jankovic, Momcilo

AU - Terracini, Benedetto

AU - Merletti, Franco

AU - Pastore, Guido

N1 - Funding Information: This study was partially supported by the Italian Association for Cancer Research and Compagnia San Paolo/FIRMS. The funding association had no role in the design of this study, the data collection, the analysis and interpretation of the results, or the writing of the manuscript. The authors thank Ms. Assunta Rasulo and Lucia Nonnato for the careful conduct of the follow-up.

PY - 2008/6

Y1 - 2008/6

N2 - We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

AB - We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

KW - Cancer registration

KW - Childhood cancer

KW - Gender

KW - Italy

KW - Survival

UR - https://www.scopus.com/pages/publications/44449165856

U2 - 10.1016/j.ejca.2008.03.020

DO - 10.1016/j.ejca.2008.03.020

M3 - Article

SN - 0959-8049

VL - 44

SP - 1282

EP - 1289

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 9

ER -

Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)

Abstract

UN SDGs

Keywords

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