Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

S. Aime; A. S. Batsanov; M. Botta; J. A.K. Howard; M. P. Lowe; D. Parker

doi:10.1039/a901704f

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

S. Aime
, A. S. Batsanov
, M. Botta
, J. A.K. Howard
, M. P. Lowe
, D. Parker

Research output: Contribution to journal › Article › peer-review

Abstract

Octadentate N₅O₃ ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/²⁹⁸ = 2.7 x 10⁶ s^-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/²⁹⁸ = 5.3 mM^-1 s^-1, 20 MHz).

Original language	English
Pages (from-to)	669-670
Number of pages	2
Journal	New Journal of Chemistry
Volume	23
Issue number	7
DOIs	https://doi.org/10.1039/a901704f
Publication status	Published - 1999
Externally published	Yes

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title = "Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents",

abstract = "Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) {\AA}], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).",

author = "S. Aime and Batsanov, \{A. S.\} and M. Botta and Howard, \{J. A.K.\} and Lowe, \{M. P.\} and D. Parker",

year = "1999",

doi = "10.1039/a901704f",

language = "English",

volume = "23",

pages = "669--670",

journal = "New Journal of Chemistry",

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publisher = "Royal Society of Chemistry",

number = "7",

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TY - JOUR

T1 - Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

AU - Aime, S.

AU - Batsanov, A. S.

AU - Botta, M.

AU - Howard, J. A.K.

AU - Lowe, M. P.

AU - Parker, D.

PY - 1999

Y1 - 1999

N2 - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).

AB - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd-N(py) bond [2.535(1) Å], and the water exchange rate (k(ox)/298 = 2.7 x 106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R(1p)/298 = 5.3 mM-1 s-1, 20 MHz).

UR - https://www.scopus.com/pages/publications/0032798407

U2 - 10.1039/a901704f

DO - 10.1039/a901704f

M3 - Article

SN - 1144-0546

VL - 23

SP - 669

EP - 670

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 7

ER -

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Abstract

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