Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide

Luigi PANZA; E MODICA; F COMPOSTELLA; D COLOMBO; L FRANCHINI; M CAVALLARI; L MORI; LIBERO G DE; F. RONCHETTI

Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide

Luigi PANZA
, E MODICA
, F COMPOSTELLA
, D COLOMBO
, L FRANCHINI
, M CAVALLARI
, L MORI
, LIBERO G DE
, F. RONCHETTI

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article

Abstract

The C-sulfatide 1b was synthesized through a [2,3]-Wittig sigmatropic rearrangement and a Horner-Wadsworth-Emmons olefination as the key steps. The C-analogue 1b is less immunogenic than natural sulfatide 1a, but induces a preferential secretion of the proinflammatory cytokine IFN-γ.

Original language	English
Pages (from-to)	3255-3258
Number of pages	4
Journal	Organic Letters
Volume	8
Publication status	Published - 2006

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http://hdl.handle.net/11579/20281

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title = "Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide",

abstract = "The C-sulfatide 1b was synthesized through a [2,3]-Wittig sigmatropic rearrangement and a Horner-Wadsworth-Emmons olefination as the key steps. The C-analogue 1b is less immunogenic than natural sulfatide 1a, but induces a preferential secretion of the proinflammatory cytokine IFN-γ.",

author = "Luigi PANZA and E MODICA and F COMPOSTELLA and D COLOMBO and L FRANCHINI and M CAVALLARI and L MORI and DE, \{LIBERO G\} and F. RONCHETTI",

year = "2006",

language = "English",

volume = "8",

pages = "3255--3258",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide

AU - PANZA, Luigi

AU - MODICA, E

AU - COMPOSTELLA, F

AU - COLOMBO, D

AU - FRANCHINI, L

AU - CAVALLARI, M

AU - MORI, L

AU - DE, LIBERO G

AU - RONCHETTI, F.

PY - 2006

Y1 - 2006

N2 - The C-sulfatide 1b was synthesized through a [2,3]-Wittig sigmatropic rearrangement and a Horner-Wadsworth-Emmons olefination as the key steps. The C-analogue 1b is less immunogenic than natural sulfatide 1a, but induces a preferential secretion of the proinflammatory cytokine IFN-γ.

AB - The C-sulfatide 1b was synthesized through a [2,3]-Wittig sigmatropic rearrangement and a Horner-Wadsworth-Emmons olefination as the key steps. The C-analogue 1b is less immunogenic than natural sulfatide 1a, but induces a preferential secretion of the proinflammatory cytokine IFN-γ.

UR - https://iris.uniupo.it/handle/11579/20281

M3 - Article

SN - 1523-7060

VL - 8

SP - 3255

EP - 3258

JO - Organic Letters

JF - Organic Letters

ER -

Stereoselective Synthesis and Immunogenic Activity of the C-Analogue of Sulfatide

Abstract

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