Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

Domenico OSELLA; Mauro RAVERA; C Nervi; G Cavigiolio; M Vincenti; A Vessieres; G. Jaouen

doi:10.1002/(SICI)1099-0682(200003)2000:3&lt;491::AID-EJIC491&gt;3.0.CO;2-2

Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

Domenico OSELLA
, Mauro RAVERA
, C Nervi
, G Cavigiolio
, M Vincenti
, A Vessieres
, G. Jaouen

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17α-alkynylestradiol-[OM] derivatives {[OM] = CO₂(CO)₆; CO₂(CO)₄(dppm); Mo₂Cp₂(CO)₄; M₃(CO)₁₀, M = Ru, Os; HRu₃(CO)₉} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).

Original language	English
Pages (from-to)	491-497
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2
Publication status	Published - 2000

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10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

http://hdl.handle.net/11579/29871

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OSELLA, D., RAVERA, M., Nervi, C., Cavigiolio, G., Vincenti, M., Vessieres, A., & Jaouen, G. (2000). Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor. European Journal of Inorganic Chemistry, (3), 491-497. https://doi.org/10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

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title = "Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor",

abstract = "The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17α-alkynylestradiol-[OM] derivatives \{[OM] = CO2(CO)6; CO2(CO)4(dppm); Mo2Cp2(CO)4; M3(CO)10, M = Ru, Os; HRu3(CO)9\} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).",

author = "Domenico OSELLA and Mauro RAVERA and C Nervi and G Cavigiolio and M Vincenti and A Vessieres and G. Jaouen",

year = "2000",

doi = "10.1002/(SICI)1099-0682(200003)2000:3\<491::AID-EJIC491\>3.0.CO;2-2",

language = "English",

pages = "491--497",

journal = "European Journal of Inorganic Chemistry",

issn = "1434-1948",

publisher = "Wiley-VCH Verlag",

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OSELLA, D, RAVERA, M, Nervi, C, Cavigiolio, G, Vincenti, M, Vessieres, A & Jaouen, G 2000, 'Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor', European Journal of Inorganic Chemistry, no. 3, pp. 491-497. https://doi.org/10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

TY - JOUR

T1 - Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

AU - OSELLA, Domenico

AU - RAVERA, Mauro

AU - Nervi, C

AU - Cavigiolio, G

AU - Vincenti, M

AU - Vessieres, A

AU - Jaouen, G.

PY - 2000

Y1 - 2000

N2 - The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17α-alkynylestradiol-[OM] derivatives {[OM] = CO2(CO)6; CO2(CO)4(dppm); Mo2Cp2(CO)4; M3(CO)10, M = Ru, Os; HRu3(CO)9} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).

AB - The stabilization of carbenium ions by an adjacent organotransition metal moiety has been evaluated using the classical Deno's method as well as a new procedure based on DCI-MS spectrometry. The ability of transition metal clusters to enhance the stability of a proximate carbocationic center in 17α-alkynylestradiol-[OM] derivatives {[OM] = CO2(CO)6; CO2(CO)4(dppm); Mo2Cp2(CO)4; M3(CO)10, M = Ru, Os; HRu3(CO)9} has been related to their capacity to inactivate the estrogen receptor (affinity marker properties).

UR - https://iris.uniupo.it/handle/11579/29871

U2 - 10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

DO - 10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

M3 - Article

SN - 1434-1948

SP - 491

EP - 497

JO - European Journal of Inorganic Chemistry

JF - European Journal of Inorganic Chemistry

IS - 3

ER -

OSELLA D, RAVERA M, Nervi C, Cavigiolio G, Vincenti M, Vessieres A et al. Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor. European Journal of Inorganic Chemistry. 2000;(3):491-497. doi: 10.1002/(SICI)1099-0682(200003)2000:3<491::AID-EJIC491>3.0.CO;2-2

Stabilization of carbenium ions derived from ethynylestradiol by different adjacent organometallic moieties. Implication in the inactivation of the estrogen receptor

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