Specialization determines outcomes in inflammation and cancer

Antonio SICA

doi:10.1038/s41590-023-01592-0

Specialization determines outcomes in inflammation and cancer

Antonio SICA

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.

Original language	English
Pages (from-to)	1399-1401
Number of pages	3
Journal	Nature Immunology
Volume	9
DOIs	https://doi.org/10.1038/s41590-023-01592-0
Publication status	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
inflammaiton
macrophages
pancreatic cancer

Access to Document

10.1038/s41590-023-01592-0

https://hdl.handle.net/11579/179274

Cite this

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title = "Specialization determines outcomes in inflammation and cancer",

abstract = "The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.",

keywords = "cancer, inflammaiton, macrophages, pancreatic cancer, cancer, inflammaiton, macrophages, pancreatic cancer",

author = "Antonio SICA",

year = "2023",

doi = "10.1038/s41590-023-01592-0",

language = "English",

volume = "9",

pages = "1399--1401",

journal = "Nature Immunology",

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T1 - Specialization determines outcomes in inflammation and cancer

AU - SICA, Antonio

PY - 2023

Y1 - 2023

N2 - The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.

AB - The functional heterogeneity of macrophages has ontological and microenvironmental bases, and differentially affects pathology. In pancreatitis, tissue-resident macrophages promote protective fibrosis that favors the maintenance of pancreatic homeostasis. In pancreatic ductal adenocarcinoma, they promote tumor progression by facilitating stromal desmoplasia.

KW - cancer

KW - inflammaiton

KW - macrophages

KW - pancreatic cancer

KW - cancer

KW - inflammaiton

KW - macrophages

KW - pancreatic cancer

UR - https://iris.uniupo.it/handle/11579/179274

U2 - 10.1038/s41590-023-01592-0

DO - 10.1038/s41590-023-01592-0

M3 - Article

SN - 1529-2908

VL - 9

SP - 1399

EP - 1401

JO - Nature Immunology

JF - Nature Immunology

ER -

Specialization determines outcomes in inflammation and cancer

Abstract

UN SDGs

Keywords

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