Solvatomorphism of Moxidectin

Toni Grell; Mauro Barbero; Franco PATTARINO; Giovanni Battista GIOVENZANA; Valentina Colombo

doi:10.3390/molecules26164869

Solvatomorphism of Moxidectin

Toni Grell, Mauro Barbero, Franco PATTARINO, Giovanni Battista GIOVENZANA, Valentina Colombo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

Original language	English
Pages (from-to)	4869
Journal	Molecules
Volume	26
Issue number	16
DOIs	https://doi.org/10.3390/molecules26164869
Publication status	Published - 2021

Keywords

X-ray diffraction
moxidectin
solvatomorphism
variable-temperature PXRD

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10.3390/molecules26164869

http://hdl.handle.net/11579/128149

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title = "Solvatomorphism of Moxidectin",

abstract = "The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.",

keywords = "X-ray diffraction, moxidectin, solvatomorphism, variable-temperature PXRD, X-ray diffraction, moxidectin, solvatomorphism, variable-temperature PXRD",

author = "Toni Grell and Mauro Barbero and Franco PATTARINO and GIOVENZANA, {Giovanni Battista} and Valentina Colombo",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/molecules26164869",

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pages = "4869",

journal = "Molecules",

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T1 - Solvatomorphism of Moxidectin

AU - Grell, Toni

AU - Barbero, Mauro

AU - PATTARINO, Franco

AU - GIOVENZANA, Giovanni Battista

AU - Colombo, Valentina

PY - 2021

Y1 - 2021

N2 - The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

AB - The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

KW - X-ray diffraction

KW - moxidectin

KW - solvatomorphism

KW - variable-temperature PXRD

KW - X-ray diffraction

KW - moxidectin

KW - solvatomorphism

KW - variable-temperature PXRD

UR - https://iris.uniupo.it/handle/11579/128149

U2 - 10.3390/molecules26164869

DO - 10.3390/molecules26164869

M3 - Article

SN - 1420-3049

VL - 26

SP - 4869

JO - Molecules

JF - Molecules

IS - 16

ER -

Solvatomorphism of Moxidectin

Abstract

Keywords

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