TY - JOUR
T1 - SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis
AU - Appendino, Giovanni
AU - Prosperini, Simona
AU - Valdivia, Carola
AU - Ballero, Mauro
AU - Colombano, Giampiero
AU - Billington, Richard A.
AU - Genazzani, Armando A.
AU - Sterner, Olov
PY - 2005/8
Y1 - 2005/8
N2 - An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
AB - An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
UR - https://www.scopus.com/pages/publications/24744471405
U2 - 10.1021/np050115m
DO - 10.1021/np050115m
M3 - Article
SN - 0163-3864
VL - 68
SP - 1213
EP - 1217
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 8
ER -