Sequence of human haptoglobin cDNA: Evidence that the α and β subunits are coded by the same mRNA

G. Raugei; G. Bensi; V. Colantuoni; V. Romano; C. Santoro; F. Costanzo; R. Cortese

doi:10.1093/nar/11.17.5811

Sequence of human haptoglobin cDNA: Evidence that the α and β subunits are coded by the same mRNA

G. Raugei
, G. Bensi
, V. Colantuoni
, V. Romano
, C. Santoro
, F. Costanzo
, R. Cortese

Research output: Contribution to journal › Article › peer-review

Abstract

We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Axg residue to generate its two characteristic α and β subunits. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

Original language	English
Pages (from-to)	5811-5819
Number of pages	9
Journal	Nucleic Acids Research
Volume	11
Issue number	17
DOIs	https://doi.org/10.1093/nar/11.17.5811
Publication status	Published - 10 Sept 1983
Externally published	Yes

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title = "Sequence of human haptoglobin cDNA: Evidence that the α and β subunits are coded by the same mRNA",

abstract = "We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Axg residue to generate its two characteristic α and β subunits. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.",

author = "G. Raugei and G. Bensi and V. Colantuoni and V. Romano and C. Santoro and F. Costanzo and R. Cortese",

note = "Funding Information: The work done in Italy was financed by CNR, Progetto Finalizzato Salute dell'Uomo, Rome, Italy and by a grant from Farmitalia Spa., Milan, Italy. Funding Information: ACKNOWLEDGEMENTS We thank Wendy Moses for typing this manuscript. G.R. and G.B. have a grant from Ente Farmacologico Italiano (EFI), Naples, Italy, V.C. was supported by a long-term EMBO fellowship, C.S. by a grant from Technosysterns, Naples, Italy, and F.C. is the recipient of a training contract GBI-O47-D from the {"}Biomolecular Engineering Programme{"} of the Commission of the European Communities.",

year = "1983",

month = sep,

day = "10",

doi = "10.1093/nar/11.17.5811",

language = "English",

volume = "11",

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TY - JOUR

T1 - Sequence of human haptoglobin cDNA

T2 - Evidence that the α and β subunits are coded by the same mRNA

AU - Raugei, G.

AU - Bensi, G.

AU - Colantuoni, V.

AU - Romano, V.

AU - Santoro, C.

AU - Costanzo, F.

AU - Cortese, R.

N1 - Funding Information: The work done in Italy was financed by CNR, Progetto Finalizzato Salute dell'Uomo, Rome, Italy and by a grant from Farmitalia Spa., Milan, Italy. Funding Information: ACKNOWLEDGEMENTS We thank Wendy Moses for typing this manuscript. G.R. and G.B. have a grant from Ente Farmacologico Italiano (EFI), Naples, Italy, V.C. was supported by a long-term EMBO fellowship, C.S. by a grant from Technosysterns, Naples, Italy, and F.C. is the recipient of a training contract GBI-O47-D from the "Biomolecular Engineering Programme" of the Commission of the European Communities.

PY - 1983/9/10

Y1 - 1983/9/10

N2 - We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Axg residue to generate its two characteristic α and β subunits. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

AB - We have isolated and sequenced a cDNA clone coding for human haptoglobin. Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Axg residue to generate its two characteristic α and β subunits. Southern blot analysis suggests that there are at least two copies of the haptoglobin gene per haploid genome.

UR - https://www.scopus.com/pages/publications/0021099977

U2 - 10.1093/nar/11.17.5811

DO - 10.1093/nar/11.17.5811

M3 - Article

SN - 0305-1048

VL - 11

SP - 5811

EP - 5819

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - 17

ER -

Sequence of human haptoglobin cDNA: Evidence that the α and β subunits are coded by the same mRNA

Abstract

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