TY - JOUR
T1 - Rhein
T2 - an anthraquinone that modulates superoxide anion production from human neutrophils
AU - Mian, M.
AU - Brunelleschi, S.
AU - Tarli, S.
AU - Rubino, A.
AU - Benetti, D.
AU - Fantozzi, R.
AU - Zilletti, L.
PY - 1987/10
Y1 - 1987/10
N2 - Rhein (4,5‐dihydroxyanthraquinone‐2‐carboxylic acid), the active metabolite of diacetylrhein, which has been reported as an effective antirheumatic drug in man, inhibited superoxide anion production from human neutrophils challenged with N‐formylmethionyl‐leucyl‐phenylalanine (FMLP: IC50, 2 times 10−5M) and A23186 (IC50, 10−5M), but not with phorbol myristate acetate. In the same concentration range (10−6‐10−3M), the drug did not affect oxy‐radical production by a cell‐free hypoxanthine‐xanthine oxidase system and exerted weak inhibitory effects on FMLP‐evoked lysosomal enzyme release. Rhein inhibitory effects on neutrophil functioning may contribute to the overall therapeutic activity of the parent drug, diacetylrhein. 1987 Royal Pharmaceutical Society of Great Britain
AB - Rhein (4,5‐dihydroxyanthraquinone‐2‐carboxylic acid), the active metabolite of diacetylrhein, which has been reported as an effective antirheumatic drug in man, inhibited superoxide anion production from human neutrophils challenged with N‐formylmethionyl‐leucyl‐phenylalanine (FMLP: IC50, 2 times 10−5M) and A23186 (IC50, 10−5M), but not with phorbol myristate acetate. In the same concentration range (10−6‐10−3M), the drug did not affect oxy‐radical production by a cell‐free hypoxanthine‐xanthine oxidase system and exerted weak inhibitory effects on FMLP‐evoked lysosomal enzyme release. Rhein inhibitory effects on neutrophil functioning may contribute to the overall therapeutic activity of the parent drug, diacetylrhein. 1987 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0023547655&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1987.tb05131.x
DO - 10.1111/j.2042-7158.1987.tb05131.x
M3 - Article
SN - 0022-3573
VL - 39
SP - 845
EP - 847
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 10
ER -