Abstract
The renal handling of human interferon-γ has been evaluated by using an isolated and perfused rabbit kidney. IFN-γ disappears from plasma with a tl/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-α are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-α is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.
Original language | English |
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Pages (from-to) | 347-352 |
Number of pages | 6 |
Journal | Journal of Interferon Research |
Volume | 1 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1981 |
Externally published | Yes |