Renal Filtration, Absorption and Catabolism of Human Alpha Interferon

V. Bocci, A. Pacini, M. Muscettola, L. Paulesu, G. P. Pessina, M. Santiano, I. Viano

Research output: Contribution to journalArticlepeer-review

Abstract

The renal handling of human interferon-γ has been evaluated by using an isolated and perfused rabbit kidney. IFN-γ disappears from plasma with a tl/2 of 81 min and the fractional turnover rate is 0.84%/min. About 47 molecules of IFN-α are filtrated with 100 molecules of creatinine but most of the IFN is absorbed by tubular cells. This is the first report showing that human IFN-α is filtrated by the kidney, largely absorbed, most probably catabolized within tubular epithelium and excreted in negligible amounts with the urine.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalJournal of Interferon Research
Volume1
Issue number3
DOIs
Publication statusPublished - 1981
Externally publishedYes

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