TY - GEN
T1 - Relapsing-remitting multiple scleroris and the role of vitamin D
T2 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM BCB 2014
AU - Pappalardo, Francesco
AU - Pennisi, Marzio
AU - Rajput, Abdul Mateen
AU - Chiacchio, Ferdinando
AU - Motta, Santo
N1 - Publisher Copyright:
Copyright © 2014 ACM.
PY - 2014/9/20
Y1 - 2014/9/20
N2 - Multiple sclerosis is an appalling disease which destroys the insulatic covers of the connections between neurons, causing disability and death. Its etiology is not yet fully understood and causes remain still unknown; therefore mathematical and computational models can help to test and verify biological hypoteses, and to understand the immune mechanisms involved. We present an extension of an agent based model that demonstrated able to describe the most common form of multiple sclerosis (relapsing-remitting) coupled with the presence of an important external factor that can improve the disease course: Vitamin D. We investigate the role of Vitamin D by a qualitative point of view, taking into account its well known immunomodulatory mechanisms.
AB - Multiple sclerosis is an appalling disease which destroys the insulatic covers of the connections between neurons, causing disability and death. Its etiology is not yet fully understood and causes remain still unknown; therefore mathematical and computational models can help to test and verify biological hypoteses, and to understand the immune mechanisms involved. We present an extension of an agent based model that demonstrated able to describe the most common form of multiple sclerosis (relapsing-remitting) coupled with the presence of an important external factor that can improve the disease course: Vitamin D. We investigate the role of Vitamin D by a qualitative point of view, taking into account its well known immunomodulatory mechanisms.
UR - https://www.scopus.com/pages/publications/84920736202
U2 - 10.1145/2649387.2660844
DO - 10.1145/2649387.2660844
M3 - Conference contribution
AN - SCOPUS:84920736202
T3 - ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
SP - 744
EP - 748
BT - ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics
PB - Association for Computing Machinery
Y2 - 20 September 2014 through 23 September 2014
ER -