Reference values for exhaled nitric oxide (reveno) study

Mario Olivieri; Giorgio Talamini; Massimo Corradi; Luigi Perbellini; Antonio Mutti; Claudio Tantucci; Mario Malerba

doi:10.1186/1465-9921-7-94

Reference values for exhaled nitric oxide (reveno) study

Mario Olivieri
, Giorgio Talamini
, Massimo Corradi
, Luigi Perbellini
, Antonio Mutti
, Claudio Tantucci
, Mario Malerba

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Despite the widespread use of fractional exhaled nitric oxide (FE_NO) as a biomarker of airways inflammation, there are no published papers describing normal FE_NO values in a large group of healthy adults. Objective: The aim of this study was to establish adult FE_NO reference values according to the international guidelines. Methods: FE_NO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. Results: The main result of the study was the significant difference in FE_NO values between men and women, thus indicating that gender-based reference FE_NO values are necessary. The FE_NO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. Conclusion: We propose reference FE_NO value s for healthy adult men and women that could be used for clinical and research purposes.

Original language	English
Article number	94
Journal	Respiratory Research
Volume	7
DOIs	https://doi.org/10.1186/1465-9921-7-94
Publication status	Published - 2006
Externally published	Yes

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title = "Reference values for exhaled nitric oxide (reveno) study",

abstract = "Background: Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults. Objective: The aim of this study was to establish adult FENO reference values according to the international guidelines. Methods: FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. Results: The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. Conclusion: We propose reference FENO value s for healthy adult men and women that could be used for clinical and research purposes.",

author = "Mario Olivieri and Giorgio Talamini and Massimo Corradi and Luigi Perbellini and Antonio Mutti and Claudio Tantucci and Mario Malerba",

year = "2006",

doi = "10.1186/1465-9921-7-94",

language = "English",

volume = "7",

journal = "Respiratory Research",

issn = "1465-993X",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Reference values for exhaled nitric oxide (reveno) study

AU - Olivieri, Mario

AU - Talamini, Giorgio

AU - Corradi, Massimo

AU - Perbellini, Luigi

AU - Mutti, Antonio

AU - Tantucci, Claudio

AU - Malerba, Mario

PY - 2006

Y1 - 2006

N2 - Background: Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults. Objective: The aim of this study was to establish adult FENO reference values according to the international guidelines. Methods: FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. Results: The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. Conclusion: We propose reference FENO value s for healthy adult men and women that could be used for clinical and research purposes.

AB - Background: Despite the widespread use of fractional exhaled nitric oxide (FENO) as a biomarker of airways inflammation, there are no published papers describing normal FENO values in a large group of healthy adults. Objective: The aim of this study was to establish adult FENO reference values according to the international guidelines. Methods: FENO was measured in 204 healthy, non-smoking adults with normal spirometry values using the on-line single-breath technique, and the results were analysed chemiluminescently. Results: The main result of the study was the significant difference in FENO values between men and women, thus indicating that gender-based reference FENO values are necessary. The FENO levels obtained at expiratory flows of 50 ml/s ranged from 2.6 to 28.8 ppb in men, and from 1.6 to 21.5 ppb in women. Conclusion: We propose reference FENO value s for healthy adult men and women that could be used for clinical and research purposes.

UR - https://www.scopus.com/pages/publications/33747015293

U2 - 10.1186/1465-9921-7-94

DO - 10.1186/1465-9921-7-94

M3 - Article

SN - 1465-993X

VL - 7

JO - Respiratory Research

JF - Respiratory Research

M1 - 94

ER -

Reference values for exhaled nitric oxide (reveno) study

Abstract

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