Reductive amination with zinc powder in aqueous media

Giovanni B. Giovenzana; Daniela Imperio; Andrea Penoni; Giovanni Palmisano

doi:10.3762/bjoc.7.125

Reductive amination with zinc powder in aqueous media

Giovanni B. Giovenzana
, Daniela Imperio
, Andrea Penoni
, Giovanni Palmisano

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.

Original language	English
Article number	125
Pages (from-to)	1095-1099
Number of pages	5
Journal	Beilstein Journal of Organic Chemistry
Volume	7
DOIs	https://doi.org/10.3762/bjoc.7.125
Publication status	Published - 10 Aug 2011

Keywords

Aldehydes
Amines
Reductive amination
Water
Zinc

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10.3762/bjoc.7.125

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title = "Reductive amination with zinc powder in aqueous media",

abstract = "Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.",

keywords = "Aldehydes, Amines, Reductive amination, Water, Zinc",

author = "Giovenzana, \{Giovanni B.\} and Daniela Imperio and Andrea Penoni and Giovanni Palmisano",

year = "2011",

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doi = "10.3762/bjoc.7.125",

language = "English",

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AU - Giovenzana, Giovanni B.

AU - Imperio, Daniela

AU - Penoni, Andrea

AU - Palmisano, Giovanni

PY - 2011/8/10

Y1 - 2011/8/10

N2 - Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.

AB - Zinc powder in aqueous alkaline media was employed to perform reductive amination of aldehydes with primary amines. The corresponding secondary amines were obtained in good yields along with minor amounts of hydrodimerization byproducts. The protocol is a green alternative to the use of complex hydrides in chlorinated or highly flammable solvents.

KW - Aldehydes

KW - Amines

KW - Reductive amination

KW - Water

KW - Zinc

UR - https://www.scopus.com/pages/publications/80051756144

U2 - 10.3762/bjoc.7.125

DO - 10.3762/bjoc.7.125

M3 - Article

SN - 1860-5397

VL - 7

SP - 1095

EP - 1099

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

M1 - 125

ER -

Reductive amination with zinc powder in aqueous media

Abstract

Keywords

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