Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection

L. Silvestro; I. Viano; C. Baiocchi; G. Saini; F. Marmont; R. Ferro

doi:10.1016/0378-4347(91)80054-G

Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection

L. Silvestro, I. Viano, C. Baiocchi, G. Saini, F. Marmont, R. Ferro

Research output: Contribution to journal › Article › peer-review

Abstract

An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.

Original language	English
Pages (from-to)	443-450
Number of pages	8
Journal	Journal of Chromatography B: Biomedical Sciences and Applications
Volume	563
Issue number	2
DOIs	https://doi.org/10.1016/0378-4347(91)80054-G
Publication status	Published - 15 Feb 1991
Externally published	Yes

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10.1016/0378-4347(91)80054-G

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title = "Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection",

abstract = "An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.",

author = "L. Silvestro and I. Viano and C. Baiocchi and G. Saini and F. Marmont and R. Ferro",

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AU - Silvestro, L.

AU - Viano, I.

AU - Baiocchi, C.

AU - Saini, G.

AU - Marmont, F.

AU - Ferro, R.

PY - 1991/2/15

Y1 - 1991/2/15

N2 - An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.

AB - An analytical procedure for the separation and determination of melphalan in human plasma was carried out. A simple high-performance liquid chromatographic method with electrochemical detection was developed taking advantage of the high sensitivity of the electrode redox reaction. The sample pretreatment consisted of a direct extraction of the interferents rather than of melphalan, owing to the difficulty of extraction of the drug, and was very simple, rapid and reproducible.

UR - https://www.scopus.com/pages/publications/0025967727

U2 - 10.1016/0378-4347(91)80054-G

DO - 10.1016/0378-4347(91)80054-G

M3 - Article

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JO - Journal of Chromatography B: Biomedical Sciences and Applications

JF - Journal of Chromatography B: Biomedical Sciences and Applications

IS - 2

ER -

Quantitation of melphalan in plasma of patients by reversed-phase high-performance liquid chromatography with electrochemical detection

Abstract

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