Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Elisabetta GABANO; Mauro RAVERA; Domenico OSELLA

doi:10.1039/c4dt00911h

Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Elisabetta GABANO
, Mauro RAVERA
, Domenico OSELLA

Research output: Contribution to journal › Article › peer-review

Abstract

This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.

Original language	English
Pages (from-to)	9813-9820
Journal	Dalton Transactions
Volume	43
DOIs	https://doi.org/10.1039/c4dt00911h
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c4dt00911h

http://hdl.handle.net/11579/54771

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title = "Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one",

abstract = "This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.",

author = "Elisabetta GABANO and Mauro RAVERA and Domenico OSELLA",

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AU - RAVERA, Mauro

AU - OSELLA, Domenico

PY - 2014

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AB - This article evaluates the efficacy and applicability of bifunctional prodrugs consisting of a six-coordinate Pt(iv) octahedral core and one or more bioactive molecules. The platinum(iv) complexes release upon reduction the corresponding cytotoxic Pt(ii) agents and the bioactive molecules, able to inhibit some biochemical mechanisms of cancer growth and/or prevent the deactivation of the Pt(ii) metabolites.

UR - https://iris.uniupo.it/handle/11579/54771

U2 - 10.1039/c4dt00911h

DO - 10.1039/c4dt00911h

M3 - Article

SN - 1477-9226

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EP - 9820

JO - Dalton Transactions

JF - Dalton Transactions

ER -

Pros and cons of bifunctional platinum(iv) antitumor prodrugs: two are (not always) better than one

Abstract

UN SDGs

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