Proprietà biologiche ed organizzazione genomica della famiglia di geni interferon-inducibile murina Ifi200 e della controparte umana HIN200

M. De Andrea; D. Gioia; B. Azzimonti; E. Noris; S. Landolfo; M. Gariglio

Proprietà biologiche ed organizzazione genomica della famiglia di geni interferon-inducibile murina Ifi200 e della controparte umana HIN200

Translated title of the contribution: Biological properties and genomic organization of the family of Interferon-inducible murine Ifi 200 and its human counterpart HIN200

M. De Andrea
, D. Gioia
, B. Azzimonti
, E. Noris
, S. Landolfo
, M. Gariglio

Research output: Contribution to journal › Article › peer-review

Abstract

Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immunomodulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (α and β) and type II (γ) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.

Translated title of the contribution	Biological properties and genomic organization of the family of Interferon-inducible murine Ifi 200 and its human counterpart HIN200
Original language	Italian
Pages (from-to)	135-145
Number of pages	11
Journal	Igiene Moderna
Volume	119
Issue number	3
Publication status	Published - 2003

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Propriet{\`a} biologiche ed organizzazione genomica della famiglia di geni interferon-inducibile murina Ifi200 e della controparte umana HIN200",

abstract = "Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immunomodulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (α and β) and type II (γ) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.",

keywords = "HIN200, Ifi200, Interferon, Interferon-inducibile",

author = "\{De Andrea\}, M. and D. Gioia and B. Azzimonti and E. Noris and S. Landolfo and M. Gariglio",

year = "2003",

language = "Italian",

volume = "119",

pages = "135--145",

journal = "Igiene Moderna",

issn = "0019-1655",

publisher = "European Journals of Epidemiology Publishers",

number = "3",

}

TY - JOUR

T1 - Proprietà biologiche ed organizzazione genomica della famiglia di geni interferon-inducibile murina Ifi200 e della controparte umana HIN200

AU - De Andrea, M.

AU - Gioia, D.

AU - Azzimonti, B.

AU - Noris, E.

AU - Landolfo, S.

AU - Gariglio, M.

PY - 2003

Y1 - 2003

N2 - Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immunomodulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (α and β) and type II (γ) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.

AB - Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immunomodulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (α and β) and type II (γ) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.

KW - HIN200

KW - Ifi200

KW - Interferon

KW - Interferon-inducibile

UR - https://www.scopus.com/pages/publications/33846275866

M3 - Articolo in rivista

SN - 0019-1655

VL - 119

SP - 135

EP - 145

JO - Igiene Moderna

JF - Igiene Moderna

IS - 3

ER -

Proprietà biologiche ed organizzazione genomica della famiglia di geni interferon-inducibile murina Ifi200 e della controparte umana HIN200

Abstract

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