Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU

doi:10.21873/INVIVO.12711

Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO₂/FiO₂) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO₂/FiO₂ difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO₂/FiO₂ difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.

Original language	English
Pages (from-to)	361-370
Number of pages	10
Journal	In Vivo
Volume	36
Issue number	1
DOIs	https://doi.org/10.21873/INVIVO.12711
Publication status	Published - Feb 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Meta-analysis
Oxygenation
Prone position
Respiratory distress

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10.21873/INVIVO.12711

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THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU (2022). Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data. In Vivo, 36(1), 361-370. https://doi.org/10.21873/INVIVO.12711

THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU. / Prone Positioning in Patients with COVID-19 : Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data. In: In Vivo. 2022 ; Vol. 36, No. 1. pp. 361-370.

@article{91f632e8bd7d468f88275e8b22fb4459,

title = "Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data",

abstract = "Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators{\textquoteright} groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55\% males, 57\% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r={\textendash}0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73\% males, 59\% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95\% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.",

keywords = "COVID-19, Meta-analysis, Oxygenation, Prone position, Respiratory distress",

author = "\{THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU\} and Anastasios Kollias and Kyriakoulis, \{Konstantinos G.\} and Vasiliki Rapti and Trontzas, \{Ioannis P.\} and Thomas Nitsotolis and Konstantinos Syrigos and Garyphallia Poulakou",

year = "2022",

month = feb,

doi = "10.21873/INVIVO.12711",

language = "English",

volume = "36",

pages = "361--370",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "1",

}

THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU 2022, 'Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data', In Vivo, vol. 36, no. 1, pp. 361-370. https://doi.org/10.21873/INVIVO.12711

Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data. / THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU.
In: In Vivo, Vol. 36, No. 1, 02.2022, p. 361-370.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prone Positioning in Patients with COVID-19

T2 - Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

AU - THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKAL

AU - Kollias, Anastasios

AU - Kyriakoulis, Konstantinos G.

AU - Rapti, Vasiliki

AU - Trontzas, Ioannis P.

AU - Nitsotolis, Thomas

AU - Syrigos, Konstantinos

AU - Poulakou, Garyphallia

PY - 2022/2

Y1 - 2022/2

N2 - Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.

AB - Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19.

KW - COVID-19

KW - Meta-analysis

KW - Oxygenation

KW - Prone position

KW - Respiratory distress

UR - https://www.scopus.com/pages/publications/85123036735

U2 - 10.21873/INVIVO.12711

DO - 10.21873/INVIVO.12711

M3 - Article

SN - 0258-851X

VL - 36

SP - 361

EP - 370

JO - In Vivo

JF - In Vivo

IS - 1

ER -

THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU. Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data. In Vivo. 2022 Feb;36(1):361-370. doi: 10.21873/INVIVO.12711

Prone Positioning in Patients with COVID-19: Analysis of Multicenter Registry Data and Meta-analysis of Aggregate Data

Abstract

UN SDGs

Keywords

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