Abstract
The possibility that Proclactin-induced grooming involves the nigrostriatal dopaminergic system was studied. Intracerebroventricular injection of rat Prolactin (PRL) in an amount of 10 μg induced grooming in male rats, and neostriatal injection of haloperidol (1 μg/1 μl) markedly suppressed this effect. Local administration of 6-OHDA in t he substantia nigra also abolished the influence of intracerebroventricularly administered PRL. Bilateral injections of PRL (10 μg/1 μl) in the neostriatum failed to induce grooming, whereas bilateral injections of peptide into the substantia nigra (1 μg/0.5 μl) elicited the behavioral response. It is probable that PRL induces grooming in the rat by interacting with the nigrostriatal dopaminergic transmission through an action on the cell bodies rather than in presynaptic terminals or at the postsynaptic level of this system.
| Original language | English |
|---|---|
| Pages (from-to) | 61-63 |
| Number of pages | 3 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1981 |
| Externally published | Yes |
Keywords
- 6-OHDA
- Grooming behavior
- Haloperidol
- Nigrotriatal system
- Prolactin
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