TY - JOUR
T1 - Progression after AKI
T2 - UnderstanDing maladaptive repair processes to predict and identify therapeutic treatments
AU - Basile, David P.
AU - Bonventre, Joseph V.
AU - Mehta, Ravindra
AU - Nangaku, Masaomi
AU - Unwin, Robert
AU - Rosner, Mitchell H.
AU - Kellum, John A.
AU - Ronco, Claudio
N1 - Funding Information:
A complete list of participants is provided in Supplemental Appendix.
PY - 2016/3
Y1 - 2016/3
N2 - Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarDing the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury convened in April of 2014 and assigned aworking group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, incluDing an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.
AB - Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarDing the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury convened in April of 2014 and assigned aworking group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, incluDing an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.
UR - http://www.scopus.com/inward/record.url?scp=84959864378&partnerID=8YFLogxK
U2 - 10.1681/ASN.2015030309
DO - 10.1681/ASN.2015030309
M3 - Article
SN - 1046-6673
VL - 27
SP - 687
EP - 697
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
IS - 3
ER -