Priming effects of mammalian tachykinins on human neutrophils

Sandra Brunelleschi; Sandra Tarli; Alberto Giotti; Roberto Fantozzi

doi:10.1016/0024-3205(91)90416-9

Priming effects of mammalian tachykinins on human neutrophils

Sandra Brunelleschi
, Sandra Tarli
, Alberto Giotti
, Roberto Fantozzi

Research output: Contribution to journal › Article › peer-review

Abstract

The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.

Original language	English
Pages (from-to)	PL1
Journal	Life Sciences
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(91)90416-9
Publication status	Published - 1991
Externally published	Yes

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title = "Priming effects of mammalian tachykinins on human neutrophils",

abstract = "The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.",

author = "Sandra Brunelleschi and Sandra Tarli and Alberto Giotti and Roberto Fantozzi",

note = "Funding Information: This work was supported in part by a MPI grant from the University of Ferrara.",

year = "1991",

doi = "10.1016/0024-3205(91)90416-9",

language = "English",

volume = "48",

pages = "PL1",

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TY - JOUR

T1 - Priming effects of mammalian tachykinins on human neutrophils

AU - Brunelleschi, Sandra

AU - Tarli, Sandra

AU - Giotti, Alberto

AU - Fantozzi, Roberto

N1 - Funding Information: This work was supported in part by a MPI grant from the University of Ferrara.

PY - 1991

Y1 - 1991

N2 - The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.

AB - The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM - 0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.

UR - https://www.scopus.com/pages/publications/0026025818

U2 - 10.1016/0024-3205(91)90416-9

DO - 10.1016/0024-3205(91)90416-9

M3 - Article

SN - 0024-3205

VL - 48

SP - PL1

JO - Life Sciences

JF - Life Sciences

IS - 2

ER -

Priming effects of mammalian tachykinins on human neutrophils

Abstract

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