Prevalence and characteristics of hpv infection in oropharyngeal cancer

Antonella De Stefani; Paolo Boffano; Gianluca Averono; Angela Ramella; Francesco Pia; Guido Bongioannini

doi:10.1097/SCS.0b013e31826cfffa

Prevalence and characteristics of hpv infection in oropharyngeal cancer

Antonella De Stefani, Paolo Boffano, Gianluca Averono, Angela Ramella, Francesco Pia, Guido Bongioannini

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer. METHODS: The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types. RESULTS: In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05). CONCLUSIONS: A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.

Original language	English
Pages (from-to)	e40-e43
Journal	Journal of Craniofacial Surgery
Volume	24
Issue number	1
DOIs	https://doi.org/10.1097/SCS.0b013e31826cfffa
Publication status	Published - Jan 2013
Externally published	Yes

Keywords

HPV
oropharyngeal cancer
outcome
prognostic factors
tumor grading

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/SCS.0b013e31826cfffa

Cite this

@article{ea7868169ba740158f268e6c6629019e,

title = "Prevalence and characteristics of hpv infection in oropharyngeal cancer",

abstract = "BACKGROUND: The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer. METHODS: The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types. RESULTS: In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05). CONCLUSIONS: A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.",

keywords = "HPV, oropharyngeal cancer, outcome, prognostic factors, tumor grading",

author = "{De Stefani}, Antonella and Paolo Boffano and Gianluca Averono and Angela Ramella and Francesco Pia and Guido Bongioannini",

year = "2013",

month = jan,

doi = "10.1097/SCS.0b013e31826cfffa",

language = "English",

volume = "24",

pages = "e40--e43",

journal = "Journal of Craniofacial Surgery",

issn = "1049-2275",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

}

TY - JOUR

T1 - Prevalence and characteristics of hpv infection in oropharyngeal cancer

AU - De Stefani, Antonella

AU - Boffano, Paolo

AU - Averono, Gianluca

AU - Ramella, Angela

AU - Pia, Francesco

AU - Bongioannini, Guido

PY - 2013/1

Y1 - 2013/1

N2 - BACKGROUND: The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer. METHODS: The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types. RESULTS: In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05). CONCLUSIONS: A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.

AB - BACKGROUND: The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer. METHODS: The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types. RESULTS: In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05). CONCLUSIONS: A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.

KW - HPV

KW - oropharyngeal cancer

KW - outcome

KW - prognostic factors

KW - tumor grading

UR - http://www.scopus.com/inward/record.url?scp=84873310699&partnerID=8YFLogxK

U2 - 10.1097/SCS.0b013e31826cfffa

DO - 10.1097/SCS.0b013e31826cfffa

M3 - Article

SN - 1049-2275

VL - 24

SP - e40-e43

JO - Journal of Craniofacial Surgery

JF - Journal of Craniofacial Surgery

IS - 1

ER -

Prevalence and characteristics of hpv infection in oropharyngeal cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this