Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

N. Kliemann; N. Murphy; V. Viallon; H. Freisling; K. K. Tsilidis; S. Rinaldi; F. R. Mancini; G. Fagherazzi; Boutron-Ruault M. -C.; H. Boeing; M. B. Schulze; G. Masala; V. Krogh; Carlotta SACERDOTE; M. S. de Magistris; B. Bueno-de-Mesquita; E. Weiderpass; T. Kuhn; R. Kaaks; P. Jakszyn; D. Redondo-Sanchez; P. Amiano; Chirlaque M. -D.; A. B. Gurrea; U. Ericson; I. Drake; T. H. Nost; D. Aune; A. M. May; A. Tjonneland; C. C. Dahm; K. Overvad; R. Tumino; J. R. Quiros; A. Trichopoulou; A. Karakatsani; Vecchia C. La; L. M. Nilsson; E. Riboli; I. Huybrechts; M. J. Gunter

doi:10.1002/ijc.32753

Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

N. Kliemann, N. Murphy, V. Viallon, H. Freisling, K. K. Tsilidis, S. Rinaldi, F. R. Mancini, G. Fagherazzi, Boutron-Ruault M. -C., H. Boeing, M. B. Schulze, G. Masala, V. Krogh, Carlotta SACERDOTE, M. S. de Magistris, B. Bueno-de-Mesquita, E. Weiderpass, T. Kuhn, R. Kaaks, P. JakszynD. Redondo-Sanchez, P. Amiano, Chirlaque M. -D., A. B. Gurrea, U. Ericson, I. Drake, T. H. Nost, D. Aune, A. M. May, A. Tjonneland, C. C. Dahm, K. Overvad, R. Tumino, J. R. Quiros, A. Trichopoulou, A. Karakatsani, Vecchia C. La, L. M. Nilsson, E. Riboli, I. Huybrechts, M. J. Gunter

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

Original language	English
Pages (from-to)	648-661
Number of pages	14
Journal	International Journal of Cancer
Volume	147
Issue number	3
DOIs	https://doi.org/10.1002/ijc.32753
Publication status	Published - 2020

Keywords

basal metabolic rate
cancer
metabolic disorder
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ijc.32753

https://hdl.handle.net/11579/199647

Cite this

Kliemann, N., Murphy, N., Viallon, V., Freisling, H., Tsilidis, K. K., Rinaldi, S., Mancini, F. R., Fagherazzi, G., -C., B.-R. M., Boeing, H., Schulze, M. B., Masala, G., Krogh, V., SACERDOTE, C., de Magistris, M. S., Bueno-de-Mesquita, B., Weiderpass, E., Kuhn, T., Kaaks, R., ... Gunter, M. J. (2020). Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 147(3), 648-661. https://doi.org/10.1002/ijc.32753

@article{ed84294efe2345ebbabe92854dafc75b,

title = "Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.",

keywords = "basal metabolic rate, cancer, metabolic disorder, obesity, basal metabolic rate, cancer, metabolic disorder, obesity",

author = "N. Kliemann and N. Murphy and V. Viallon and H. Freisling and Tsilidis, {K. K.} and S. Rinaldi and Mancini, {F. R.} and G. Fagherazzi and -C., {Boutron-Ruault M.} and H. Boeing and Schulze, {M. B.} and G. Masala and V. Krogh and Carlotta SACERDOTE and {de Magistris}, {M. S.} and B. Bueno-de-Mesquita and E. Weiderpass and T. Kuhn and R. Kaaks and P. Jakszyn and D. Redondo-Sanchez and P. Amiano and -D., {Chirlaque M.} and Gurrea, {A. B.} and U. Ericson and I. Drake and Nost, {T. H.} and D. Aune and May, {A. M.} and A. Tjonneland and Dahm, {C. C.} and K. Overvad and R. Tumino and Quiros, {J. R.} and A. Trichopoulou and A. Karakatsani and La, {Vecchia C.} and Nilsson, {L. M.} and E. Riboli and I. Huybrechts and Gunter, {M. J.}",

year = "2020",

doi = "10.1002/ijc.32753",

language = "English",

volume = "147",

pages = "648--661",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

Kliemann, N, Murphy, N, Viallon, V, Freisling, H, Tsilidis, KK, Rinaldi, S, Mancini, FR, Fagherazzi, G, -C., B-RM, Boeing, H, Schulze, MB, Masala, G, Krogh, V, SACERDOTE, C, de Magistris, MS, Bueno-de-Mesquita, B, Weiderpass, E, Kuhn, T, Kaaks, R, Jakszyn, P, Redondo-Sanchez, D, Amiano, P, -D., CM, Gurrea, AB, Ericson, U, Drake, I, Nost, TH, Aune, D, May, AM, Tjonneland, A, Dahm, CC, Overvad, K, Tumino, R, Quiros, JR, Trichopoulou, A, Karakatsani, A, La, VC, Nilsson, LM, Riboli, E, Huybrechts, I & Gunter, MJ 2020, 'Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 147, no. 3, pp. 648-661. https://doi.org/10.1002/ijc.32753

TY - JOUR

T1 - Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

AU - Kliemann, N.

AU - Murphy, N.

AU - Viallon, V.

AU - Freisling, H.

AU - Tsilidis, K. K.

AU - Rinaldi, S.

AU - Mancini, F. R.

AU - Fagherazzi, G.

AU - -C., Boutron-Ruault M.

AU - Boeing, H.

AU - Schulze, M. B.

AU - Masala, G.

AU - Krogh, V.

AU - SACERDOTE, Carlotta

AU - de Magistris, M. S.

AU - Bueno-de-Mesquita, B.

AU - Weiderpass, E.

AU - Kuhn, T.

AU - Kaaks, R.

AU - Jakszyn, P.

AU - Redondo-Sanchez, D.

AU - Amiano, P.

AU - -D., Chirlaque M.

AU - Gurrea, A. B.

AU - Ericson, U.

AU - Drake, I.

AU - Nost, T. H.

AU - Aune, D.

AU - May, A. M.

AU - Tjonneland, A.

AU - Dahm, C. C.

AU - Overvad, K.

AU - Tumino, R.

AU - Quiros, J. R.

AU - Trichopoulou, A.

AU - Karakatsani, A.

AU - La, Vecchia C.

AU - Nilsson, L. M.

AU - Riboli, E.

AU - Huybrechts, I.

AU - Gunter, M. J.

PY - 2020

Y1 - 2020

N2 - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

AB - Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.

KW - basal metabolic rate

KW - cancer

KW - metabolic disorder

KW - obesity

KW - basal metabolic rate

KW - cancer

KW - metabolic disorder

KW - obesity

UR - https://iris.uniupo.it/handle/11579/199647

U2 - 10.1002/ijc.32753

DO - 10.1002/ijc.32753

M3 - Article

SN - 0020-7136

VL - 147

SP - 648

EP - 661

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 3

ER -

Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this